LB068 - EFFECTS OF ORAL NUTRITIONAL SUPPLEMENTS ON ENERGY AND PROTEIN INTAKE AND BODY WEIGHT IN ADULTS: AN UMBRELLA REVIEW OF SYSTEMATIC REVIEWS AND META-ANALYSES

LB068

EFFECTS OF ORAL NUTRITIONAL SUPPLEMENTS ON ENERGY AND PROTEIN INTAKE AND BODY WEIGHT IN ADULTS: AN UMBRELLA REVIEW OF SYSTEMATIC REVIEWS AND META-ANALYSES

M. Rowan¹, M. Delsoglio^1,*, N. Rice², T. Smith³, E. Parsons⁴, P. Collins^5,6,7, D. Griffith⁸, G. P. Hubbard¹, R. J. Stratton^4,9,10

¹Danone Research & Innovation, Trowbridge, United Kingdom, ²Irish Society for Clinical Nutrition and Metabolism (IrSPEN), Dublin, Ireland, ³University Hospital Southampton, Southampton, ⁴Division of Food, Nutrition & Dietetics, University of Nottingham, Nottingham, United Kingdom, ⁵Department of Allied Health, Sunshine Coast Hospital and Health Service, Birtinya, ⁶The School of Health, University of the Sunshine Coast, Sunshine Coast, ⁷Sunshine Coast Health Institute, Birtinya, Australia, ⁸University Hospitals Birmingham, Birmingham, ⁹Faculty of Medicine, University of Southampton, Southampton, United Kingdom, ¹⁰Danone Global Research & Innovation Centre, Utrecht, Netherlands

Rationale: Oral nutritional supplements (ONS) are recommended in clinical guidelines to improve the nutritional intake and status of patients with disease-related malnutrition. These guidelines are informed by extensive evidence from clinical trials, systematic reviews and meta-analyses (SRMA) of ONS use. As publications have increased in recent years an up-to-date umbrella review of the evidence for ONS is warranted.

Methods: PubMed, Embase and the Cochrane Library were searched up to Sept 2025 for SRMA of trials of ONS compared with ‘controls’ (dietary advice, usual diet +/- placebo) in adults (>18y) across diseases and settings. SRMA with >10% non-ONS interventions, multi-modal designs or ONS-to-ONS comparisons were excluded. SRMA with >1 study were independently extracted in duplicate for study details and effects on total energy, protein intake and body weight.  Corrected cover area (CCA) was used to assess overlap¹.

Results: 1922 abstracts and 365 full texts were screened, yielding 33 eligible SRMA (45% published since 2021), of 419 primary studies with slight overlap (2.4% CCA)¹. Populations were mixed diagnoses (n 15, 45%), cancer (n 12, 36%), COPD (n 2, 6%), dementia (n 2, 6%), HIV/AIDS (n 1), and stroke (n 1). Compared to controls, ONS significantly increased total energy intake (15/16 MA, n>5,000) and protein intake (9/11 MA, n>3,000) and improved body weight in all MA, significantly so in 71% (24/34, n>26,000).

Conclusion: This up-to-date umbrella review of 33SRMA shows ONS use in addition to the diet improves total energy and protein intakes and body weight in adult patients more than diet alone. Further analysis will assess effects on clinical outcomes.

References: 1. Pieper et al., 2014, J Clin Epidemiol

Disclosure of Interest: M. Rowan Other: Employee of Danone, M. Delsoglio: None declared, N. Rice: None declared, T. Smith: None declared, E. Parsons: None declared, P. Collins: None declared, D. Griffith: None declared, G. Hubbard Other: Employee of Danone, R. Stratton Other: Employee of Danone