PD919 - RELATIONSHIP BETWEEN VISCERAL ADIPOSITY INDEX AND GLYCATED HEMOGLOBIN IN CHILDREN AND ADOLESCENTS WITH TYPE 1 DIABETES MELLITUS

PD919

RELATIONSHIP BETWEEN VISCERAL ADIPOSITY INDEX AND GLYCATED HEMOGLOBIN IN CHILDREN AND ADOLESCENTS WITH TYPE 1 DIABETES MELLITUS

R. R. Spinelli¹, J. Braga¹, B. B. de Araújo¹, G. França¹, G. N. Dias¹, A. B. Azevedo¹, P. Sizisnande¹, P. Padilha^1,*

¹UFRJ, Rio de Janeiro, Brazil

Rationale: The increasing incidence of Type 1 Diabetes Mellitus (T1DM) and obesity in pediatric populations underscores the need to better understand factors associated with glycemic control. Visceral adiposity, a key component of cardiometabolic risk, may influence glycemic variability in this group. However, the relationship between the visceral adiposity index (VAI) and Glycated Hemoglobin (HbA1c) remains poorly explored in children and adolescents with T1DM. Therefore, this study aimed to investigate the association between VAI and glycemic control, as assessed by HbA1c, in this population.

Methods: This cross-sectional study included 143 children and adolescents aged 7–16 years with T1DM for at least one year, followed between 2020 and 2023 at a reference center in Brazil. Clinical, sociodemographic, anthropometric, and laboratory data were collected. The VAI was calculated from body mass index, waist circumference, triglycerides, and HDL-cholesterol. Glycemic control was assessed using HbA1c, categorized into tertiles. Overweight was defined as a z-score ≥ +1. Multinomial logistic regression was used to investigate associations between adiposity markers and HbA1c tertiles, with adjustment based on glycemic index. Statistical significance was considered at p<0.05.

Results: The sample had a mean age of 11.5 ± 2.2 years, with 51% being female. The mean VAI and HbA1c were 3.75 ± 1.26 and 8.1% ± 1.1%, respectively, and one-third of the participants were overweight. VAI was significantly associated with worse glycemic control (OR: 1.62; 95% CI: 1.10–2.61; p=0.046).

Conclusion: The VAI was associated with poorer glycemic control in children and adolescents with type 1 diabetes, revealing itself to be a potential clinical marker for monitoring and early identification of cardiometabolic risk in this population.

Disclosure of Interest: None declared