LB096 - ROLE OF URIC ACID AND PERIRENAL FAT ON FAT MASS OF POST-MENOPAUSAL WOMEN

LB096

ROLE OF URIC ACID AND PERIRENAL FAT ON FAT MASS OF POST-MENOPAUSAL WOMEN

I. SIRIANNI¹, G. CIAGHI¹, A. T. FLORES^1,2, A. CATELAN¹, A. N. TIMOUMI¹, A. MARTINUZZI¹, A. COCCO¹, V. FRAMBA¹, G. BOMBONATO¹, V. TIKHONOFF^1,*

¹DEPARTMENT OF MEDICINE , ²DEPARTMENT OF LAND, ENVIRONMENT, AGRICULTURE AND FORESTRY, UNIVERSITY OF PADOVA, PADOVA, Italy

Rationale: The changing hormonal milieu in post-menopausal women (PMW) predisposes them to increase cardiovascular (CV) risk, due to a constellation of risk factors, such as visceral obesity, atherogenic dyslipidemia and arterial hypertension. Among ectopic adipose tissue sites, perirenal fat (PF) has been associated with multiple metabolic and anthropometric variables. Furthermore, the role of uric acid (UA) as a possible CV risk factor is intriguing. We aimed to investigate the role of UA in fat mass accumulation and the possible involvement of PF in relation to the metabolic context.

Methods: 88 PMW with BMI 24-39 Kg/m² and at least another CV risk factor were recruited. Anthropometric parameters (including skinfold thickness), blood pressure and blood samples were taken. Assessment of body composition using electrical bioimpedance (BIA) were performed. Questionnaires on medical history, physical activity, and food frequency were administered. Liver attenuation index and stiffness, and PF thickness were measured by abdominal ultrasound. A cross-sectional analysis on 68 complete cases were conducted. Spearmen correlations as well as multivariate linear regressions with dependent variable fat mass (FM) and independent variables UA, PF, age, smoking, alcohol, intake of proteins and lipids of animal origin, fructose intake, LDL cholesterol, serum creatinine, and arterial hypertension were performed.

Results: FM is normally distributed with a median of 28.55 Kg (25th-75th percentile 23.3-32.3) as well as PF with a median of 6.80 mm (25th-75th percentile 3.95-9.05), while logarithmic transformation was done for UA. Both UA and PF correlate with FM (r=0.37, p<0.001 and r=0.43; p<0.001, respectively), with waist circumference (r=0.30, p<0.05 and r=0.49; p<0.001, respectively), and subscapular skinfold (r=0.26, p<0.05 and r=0.40; p<0.001, respectively). PF also correlates with attenuation index and HOMA Index (r=0.48, p<0.001 and r=0.30; p<0.05, respectively). No correlation was identified between PF and UA. The determinants of absolute FM, calculated both by BIA and skinfold thickness, were serum UA, perirenal fat thickness, and arterial hypertension (Cumulative R²=0.43; p<0.0001).

Conclusion: The independent association between absolute FM, UA, and PF confirm their impact on visceral adiposity, but the lack of correlation between UA and PF suggests they act independently. Indeed, the correlation between PF, HOMA index and hepatic steatosis supports a role of PF in the context of insulin resistance.

References: Gherghina, M.-E. et al. Uric Acid and Oxidative Stress—Relationship with Cardiovascular, Metabolic, and Renal Impairment. Int. J. Mol. Sci. 23, 3188 (2022); Young, L. & Cho, L. Unique cardiovascular risk factors in women. Heart Br. Card. Soc. 105, 1656–1660 (2019); Chen, G.-C. et al. Association between regional body fat and cardiovascular disease risk among postmenopausal women with normal body mass index. Eur. Heart J. 40, 2849–2855 (2019); Jespersen NZ, et al. Heterogeneity in the perirenal region of humans suggests presence of dormant brown adipose tissue that contains brown fat precursor cells. Mol Metab. 24:30-43 (2019); Liu BX. Perirenal fat: a unique fat pad and potential target for cardiovascular disease. 70, 584–93 (2019); Katsiki, N., Dimitriadis, G. & Mikhailidis, D. P. Perirenal Adiposity and Other Excessive Intra- and Peri-Organ Fat Depots: What Is the Connection? Angiology 70, 581–583 (2019).

Disclosure of Interest: None declared