LB067 - EFFECTS OF ORAL NUTRITIONAL SUPPLEMENTS ON COMPLICATIONS IN ADULTS: AN UMBRELLA REVIEW OF SYSTEMATIC REVIEWS AND META ANALYSES

LB067

EFFECTS OF ORAL NUTRITIONAL SUPPLEMENTS ON COMPLICATIONS IN ADULTS: AN UMBRELLA REVIEW OF SYSTEMATIC REVIEWS AND META ANALYSES

M. Delsoglio^1,*, M. Rowan¹, N. Rice², T. Smith³, E. Parsons⁴, P. Collins^5,6,7, D. Griffith⁸, G. P. Hubbard¹, R. J. Stratton^4,9,10

¹Danone Research & Innovation, Trowbridge, United Kingdom, ²Irish Society for Clinical Nutrition and Metabolism (IrSPEN), Dublin, Ireland, ³University Hospital Southampton, Southampton, ⁴Division of Food, Nutrition & Dietetics, University of Nottingham, Nottingham, United Kingdom, ⁵Department of Allied Health, Sunshine Coast Hospital and Health Service, Birtinya, ⁶The School of Health, University of the Sunshine Coast, Sunshine Coast, ⁷Sunshine Coast Health Institute, Birtinya, Australia, ⁸University Hospitals Birmingham, Birmingham, ⁹Faculty of Medicine, University of Southampton, Southampton, United Kingdom, ¹⁰Danone Global Research & Innovation Centre, Utrecht, Netherlands

Rationale: Oral nutritional supplements (ONS) are used to improve nutritional and clinical outcomes in adults with disease‑related malnutrition. With the recent increase in systematic reviews and meta‑analyses (SRMA) of ONS, this umbrella review synthesised this evidence to assess the effects of ONS on clinical complications.

Methods: PubMed, Embase and the Cochrane Library were searched up to Sept 2025 for SRMA of trials of ONS use in adults (≥18 y) compared with ‘controls’ (dietary advice, usual diet +/- placebo) across diseases or settings. Reviews with >10% non‑ONS interventions, multimodal designs or ONS‑to‑ONS comparisons were excluded. For SRMA with >1 study data were independently extracted in duplicate. Outcomes included total, infectious, non-infectious and post-operative complications with subgroup analyses by setting, age and disease. Corrected cover area (CCA) was used to assess overlap¹.

Results: 1,922 abstracts and 365 full‑text articles were screened. 24 SR comprising 32 MA of 257 primary studies and >30,000 participants were included, with slight overlap (3.2% CCA)¹. 66% MA (21/32) reported significantly fewer complications with use of ONS vs. ‘controls’, and 34% MA (11/32) favoured ONS groups non-significantly. Significant benefits in MA were more frequently observed for total complications (13/17), for hip fractures (7/9), mixed patient populations (8/10), older adults (defined by authors) (7/8) and community‑based (5/8) and hospital‑only (3/3) populations.

Conclusion: This umbrella review shows use of ONS in addition to the diet in adults, is consistently associated with fewer complications, which are a key driver of healthcare use and costs, with benefits observed across community and hospital settings and patient groups, particularly older adults, hip fracture patients and mixed clinical populations.

References: 1. Pieper et al., 2014, J Clin Epidemiol

Disclosure of Interest: M. Delsoglio Other: Employee of Danone, M. Rowan Other: Employee of Danone, N. Rice: None declared, T. Smith: None declared, E. Parsons: None declared, P. Collins: None declared, D. Griffith: None declared, G. Hubbard Other: Employee of Danone, R. Stratton Other: Employee of Danone