P120 - VITAMIN E INTAKE AND SERUM STATUS, AND LIPID PROFILE IN INDIVIDUALS WITH MASLD AND OVERWEIGHT

P120

VITAMIN E INTAKE AND SERUM STATUS, AND LIPID PROFILE IN INDIVIDUALS WITH MASLD AND OVERWEIGHT

L. B. Silva^1,*, C. Bertoncini-Silva¹, N. A. de Paula¹, J.-M. Zingg², E. Z. Martinez³, D. S. Sartorelli³, V. M. M. Suen¹

¹Department of Internal Medicine, University of São Paulo, Ribeirão Preto, Brazil, ²Department of Biochemistry and Molecular Biology, University of Miami, Miami, United States, ³Department of Social Medicine, University of São Paulo, Ribeirão Preto, Brazil

Rationale: Vitamin E has been studied and recommended as an antioxidant to combat inflammation associated with metabolic dysfunction-associated steatotic liver disease (MASLD). As oxidized LDL promotes inflammation and may worsen MASLD progression (EASL-EASD-EASO, 2024), this study evaluated dietary intake and serum levels of vitamin E, along with the lipid profile, in individuals with MASLD and overweight.

Methods: A total of 131 individuals diagnosed with MASLD underwent an assessment, including BMI and waist circumference (WC) measurements, dietary intake using NutraBem software, and alcohol intake. Serum vitamin E was measured by HPLC and lipid profile by enzymatic colorimetric methods.

Results: All participants were classified as overweight or obese (BMI: 35±6 kg/m²) and had elevated WC (109±12 cm). LDL levels were elevated (91±32 mg/dL). Dietary analysis revealed high intake of total fat (38% of TEI), saturated fat (20% of TEI), and sugar (23% of TEI), with low vitamin E intake (6 mg/day). No participant reported excessive alcohol consumption. 

Conclusion: Despite inadequate vitamin E intake, 95% had serum levels within the normal range (5–20 mg/L). These findings suggest that factors beyond diet may influence serum vitamin E levels. The presence of overweight, increased WC, elevated LDL, and poor diet quality may contribute to MASLD progression and increased risk of metabolic and cardiovascular complications. The results highlight the importance of early nutritional strategies to improve diet quality and antioxidant intake, aiming to prevent disease progression.

References: European Association for the Study of the Liver (EASL), European Association for the Study of Diabetes (EASD), & European Association for the Study of Obesity (EASO) (2024). EASL-EASD-EASO Clinical Practice Guidelines on the Management of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). Obesity facts, 17(4), 374–444.

Disclosure of Interest: None declared