P384 - A COMPREHENSIVE ANALYSIS OF INFLAMMATION-NUTRITION STATUS IN ELDERLY CANCER PATIENTS WITH DIABETES MELLITUS (DM)

P384

A COMPREHENSIVE ANALYSIS OF INFLAMMATION-NUTRITION STATUS IN ELDERLY CANCER PATIENTS WITH DIABETES MELLITUS (DM)

X. Dai^1,*, X. Zhang¹, M. Cong¹

¹Department of Comprehensive Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

Rationale: As the population ages, the prevalence of diabetes mellitus (DM) and cancer has been steadily on the rise. Elderly cancer patients with DM are more prone to proinflammation and malnutrition. These combined factors significantly contribute to poor prognosis. Therefore, we systematically analyzed the inflammation-nutrition status of elderly cancer patients with DM and aimed to determine key prognostic factors.

Methods: We initially contrasted the inflammation and nutrition profiles of elderly cancer patients with DM to those without. Time-dependent ROC curves were employed to assess the predictive value of inflammation/nutrition markers. The association between these markers and OS was examined utilizing Kaplan–Meier survival analysis, along with the application of the Cox proportional hazards model.

Results: The incidence of DM was elevated in elderly cancer patients, with these patients exhibiting a heightened risk of mortality (HR=1.16, 95% CI=1.02-1.31, P=0.026). Despite no notable difference in nutritional status between the two groups, a significant difference was found in their inflammation/nutrition markers. Elderly cancer patients with DM exhibited higher levels of the neutrophil–lymphocyte ratio (NLR), systemic immune-inflammation index (SII), glucose-to-lymphocyte ratio (GLR), and neutrophil-to-albumin ratio (NAR), along with lower levels of the albumin-to-globulin ratio (AGR). The AUC of AGR for mortality was the highest. Low AGR (HR=1.67; 95% CI: 1.17–2.38; P=0.004) and high PG-SGA scores (HR=1.41; 95% CI: 1.07–1.87; P=0.015) were both independent prognosis predictors.

Conclusion: The incidence of DM in elderly cancer patients is greater than that observed in younger cancer patients. In comparison to those without DM, elderly cancer patients with DM exhibited elevated inflammation levels and poorer OS. AGR has better predictive value than other inflammation/nutrition markers.

Disclosure of Interest: None declared