PD370 - THE ROLE OF NUTRITIONAL SUPPORT IN PATIENTS WITH CROHN’S DISEASE AND CHRONIC INTESTINAL FAILURE

PD370

THE ROLE OF NUTRITIONAL SUPPORT IN PATIENTS WITH CROHN’S DISEASE AND CHRONIC INTESTINAL FAILURE

A. Šuligoj^1,*, T. Košir Božič¹, N. Rotovnik Kozjek ¹

¹Clinical Nutrition , Institute of Oncology, Ljubljana, Slovenia

Rationale: Crohn’s disease (CD) is associated with a high risk of malnutrition and chronic intestinal failure (IF). (1) The aim of the study was to evaluate the effectiveness of long-term home parenteral nutrition (HPN) on nutritional status in CD patients with Type 3 IF.

Methods: We conducted a retrospective analysis of 15 CD patients (5 females, 10 males) treated with HPN between October 2008 and October 2025 at a tertiary centre. Mean treatment duration was 4 years (range 1–15). Nutritional status was assessed at baseline and after 1, 5, 10, and 15 years. Parameters included body weight (BW), body mass index (BMI), and bioimpedance-derived fat-free mass index (FFMI) and phase angle (PhA). Changes in total body water were also evaluated. Descriptive analysis was performed.

Results: At baseline, all patients were malnourished according to GLIM criteria, with low BW, FFMI, and PhA, and elevated total body water. (2) During HPN, improvements were observed: total body water decreased by 2–29%, BW increased in 3 patients by 60–66%, PhA increased in 6 patients by 16–86%, and FFMI increased in 4 patients by 20–88%. In one patient, treatment with teduglutide enabled discontinuation of HPN. Variability in body water influenced FFMI interpretation. 

Conclusion: HPN improves nutritional status and is lifesaving in CD patients with chronic IF. Regular monitoring, including body composition analysis, is essential, although interpretation requires consideration of fluid status. Early recognition and treatment of malnutrition are critical for improving clinical outcomes.

References:         1. Santarpia L, et al. "Nutritional rehabilitation in patients with malnutrition due to Crohn’s disease." Nutrients11.12 (2019): 2947.

        2. Cederholm T, et al."GLIM criteria for the diagnosis of malnutrition–a consensus report from the global clinical nutrition community." Journal of cachexia, sarcopenia and muscle10.1 (2019): 207-217.

Disclosure of Interest: None declared