LB007 - 12 WEEKS OF TIME-RESTRICTED EATING DID NOT CHANGE PHASE ANGLE IN ADULTS WITH OVERWEIGHT OR OBESITY: A SECONDARY ANALYSIS OF A RANDOMIZED CONTROLLED TRIAL

LB007

12 WEEKS OF TIME-RESTRICTED EATING DID NOT CHANGE PHASE ANGLE IN ADULTS WITH OVERWEIGHT OR OBESITY: A SECONDARY ANALYSIS OF A RANDOMIZED CONTROLLED TRIAL

C. Hernández Martínez^1,*, J. J. Martín-Olmedo¹, A. Clavero-Jimeno¹, A. Camacho-Cardenosa¹, M. Dote-Montero^1,2, E. Merchán-Ramírez¹, L. Jurado-Fasoli^1,3,4, A. M. Silva⁵, J. R. Ruiz^1,3,4

¹University of Granada, Granada, Spain, ²National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, United States, ³Instituto de Investigación Biosanitaria, ⁴Instituto de Salud Carlos III, Granada, Spain, ⁵Universidade de Lisboa, Lisboa, Portugal

Rationale: Time-restricted eating (TRE) has emerged as a promising weight-loss strategy for individuals with obesity. Despite assessments of body composition and cardiometabolic risk markers during obesity interventions, phase angle (PhA), a prognostic indicator in several clinical settings, remains underexplored. We aimed to investigate the effects of three TRE schedules (early, late and self-selected, 8h eating window) compared with usual care (UC, ≥12h eating window) on PhA and raw bioelectrical impedance (BIA) variables (resistance, R; and reactance, Xc) in adults with overweight or obesity over 12 weeks.

Methods: This secondary study of a randomized controlled trial included 99 participants (49% women) with overweight or obesity, who were assigned to UC (n=25), early TRE (n=25), late TRE (n=27) or self-selected TRE (n=22). Body composition was estimated by a multi-frequency BIA device, ectopic fat was quantified by magnetic resonance imaging, and cardiometabolic risk markers were assessed before and after the intervention. Linear mixed models and correlation analyses were performed.

Results: No significant differences were noted in changes in PhA (all P≥0.08) or raw BIA variables (all P≥0.06) across all groups. We did not observe correlations between changes in PhA and changes in body composition variables (all P≥0.12) or cardiometabolic risk markers (all P≥0.19). However, changes in R were negatively associated with changes in fat-free mass, hip girth, abdominal subcutaneous adipose tissue, and liver fat fraction (all P<0.05).

Conclusion: Compared with UC, 12-week TRE interventions did not significantly change PhA or raw BIA-related variables in participants with overweight or obesity. However, raw BIA variables may capture adiposity-related shifts not reflected by PhA, warranting further investigation in longer or more intensive interventions.

Disclosure of Interest: None declared