P341 - FAT-FREE MASS (FFM) IN ONCOLOGICAL TREATMENT (OT) AND SURVIVAL IN HEAD AND NECK CANCER (HNC) PATIENTS

P341

FAT-FREE MASS (FFM) IN ONCOLOGICAL TREATMENT (OT) AND SURVIVAL IN HEAD AND NECK CANCER (HNC) PATIENTS

L. Andurell^1,*, M. Gómez¹, F. Mucarzel¹, F. Palmas¹, M. Ricart¹, A. Lluch¹, G. Cárdenas¹, R. Cartiel¹, V. Avilés¹, M. Giribés¹, A. Zabalegui¹, H. Segurola¹, R. Burgos¹

¹Nutritional Suport Unit, Vall d'Hebron University Hospital, Barcelona, Spain

 

Rationale: Body composition techniques must be included in the nutritional assessment of the HNC patients.BIA is a non-invasive technique, very useful to measure patient’s evolution.  

The aim was to know the prevalence of malnutrition(MN) and low muscle mass and the influence of FFM on OT tolerance and survival in HNC patients.

Methods: Observational, longitudinal and prospective study including patients with HNC who received radiotherapy(RT) between April’22-October’24.

Variables Included: Bioimpedance:AkernBIA-101, FFM(%,Kg), appendicular muscle mass(ASM)(Kg), Phase angle(º)(PA)y %weight loss(WL),MN(GLIM Criteria)and prognostic.

Measurements were taken before the start of RT(v0), 30-35RT(v3), 3 months after RT(v5).

Results: 65patients were included, mean age64±12years, 69,2%male, 58,4%received concurrent treatment with RT and 61,5% had undergone surgery.

	V0	V3	V5
NonMN	30(46,2%)	19(31,1%)	17(34,0%)
ModerateMN	27(41,5%)	19(31,1%)	16(32%)
SevereMN	8(12,3%)	23(37,7%)	17(34%)
Lowmusclemass(ASM)	8(13,8%)	9(20%)	5(10,2%)

 

The risk of developing mucositis≥G2 is, 5 and 9.2 times higher in patients who lost ≥0,9kg or 1,61%ofFFM during treatment, respectively.(OR5 IC95%[1,47-17,46]p>0,001) (OR9,2 IC95%[2,54-33,3]p<0,001)

In our sample, there is a significant association between the reduction in FFM(p=0,022) and PA (p=0,032),betweenV3-V5, and a worse prognosis. Specifically, 2.75% of FFM reduction is the value with more predictive power in relation with mortality.

Instead, theWL(%) considered a classical variable and included in the GLIM criteria, doesn’t significantly predict mortality(p=0,25).

Conclusion:  

There is an increased risk of MN and low muscle mass in patients with HNC in OT.

The decrease in FFM during treatment is associated with the presence of mucositis.

The reduction in FFM and AF at the end of the treatment may be associated with a worse prognosis, regardless of total weight loss.

Disclosure of Interest: None declared