P563 - MUSCLE ASSESSMENT AND FUNCTIONAL RECOVERY IN COLON CANCER SURGERY PATIENTS

P563

MUSCLE ASSESSMENT AND FUNCTIONAL RECOVERY IN COLON CANCER SURGERY PATIENTS

F. Mucarzel Suarez-Arana^1,*, F. X. Palmas Candia¹, M. Ricart Viles¹, A. Lluch Romero¹, R. Cartiel Vesperina¹, A. Rodriguez², A. Zabalegui Eguinoa¹, R. Burgos Peláez¹

¹Endocrinology and Nutrition Department, ²Department of Radiology, Hospital Vall d'Hebron, Barcelona, Spain

Rationale: Body composition(BC) influences in functional recovery after surgery(AS) but is often overlooked. This study aims to track changes in muscle mass, its quality and function of patients with colon cancer(CC) over 6 months AS.

Methods: Prospective study including patients with CC undergoing surgery, with 6 months follow-up at a tertiary hospital. Sarcopenia and malnutrition were assessed(using EWGSOP2 and GLIM criteria). BC was measured by: CT at L3(muscle area and density (Hounsfield Units,HU)) and Ultrasound imaging at  rectus femoris(RF)(muscle area(cm²), thickness(cm) and echogenicity(mean grayscale). Functional capacity(FC) was assessed by handgrip strength(HG) and the Short Physical Performance Battery(SPPB) test.

Results: 154 patients were included, mean age of 71.5 years, 64.3% males. At baseline, malnutrition prevalence was 51.9%. The7.1% were at risk for sarcopenia and 21.4% presented dynapenia. Significant changes in BC and FC were observed during the follow-up. Area of the RF increased by a median of 0.21 cm(p=0.001) and muscle thickness by 0.04 cm(p =0.004). Using CT, muscle mass increased 11.8±15.6cm²(p<0.001) and muscle density(UH) decreased 5.6±8.0(p<0.001). Considering FC, HG raised by 1.78 kg(p=0.001). Strength status was explained with muscle quantity measured by TC and US (r2=0,47;r=0,69;p<0,001). From SPPB, the chair rise test(CRT) results improved by a decrease in time by 0.48 seconds(p=0.002), and walking speed by 17 seconds(p=0.008). Functionality measured by the CRT was associated only with muscle quality(density and echogenicity) (r2=0,12;r=0,37;p<0,001).

Conclusion: Muscle quantity is a key predictor of strength status, but muscle quality(through density and echogenicity) has an important role when considering functionality. These findings highlight the importance of assessing muscle quality and providing targeted nutrition and rehabilitation to enhance recovery.

Disclosure of Interest: None declared