PD434 - FAT MASS ASSESSMENT BY BIVA AND ULTRASOUND IN AMYOTROPHIC LATERAL SCLEROSIS:ASSOCIATION WITH NUTRITIONAL STATUS (NUTRIELA PROJECT).

PD434

FAT MASS ASSESSMENT BY BIVA AND ULTRASOUND IN AMYOTROPHIC LATERAL SCLEROSIS:

ASSOCIATION WITH NUTRITIONAL STATUS (NUTRIELA PROJECT).

M. De Damas Medina^1,* on behalf of NUTRIELA, A. Segarra Balao¹, M. I. Rebollo Pérez², S. Quintana Arroyo³, F. J. Vílchez López⁴

¹Hospital Universitario de Jaén, Jaén, ²Hospital Universitario Juan Ramón Jiménez, Huelva, ³Complejo Hospitalario Universitario Insular Materno Infantil de Gran Canaria, Las Palmas de Gran Canaria, ⁴Hospital Universitario Puerta del Mar, Cádiz, Spain

Rationale: In Amyotrophic Lateral Sclerosis (ALS), lean mass declines due to disease progression regardless of nutritional status. Therefore, fat mass assessment is especially relevant for nutritional evaluation and follow-up.

Methods: Ambispective multicenter observational study in patients with ALS. Nutritional status was classified according to GLIM criteria (well-nourished, moderately or severely malnourished). Fat mass by BIVA and abdominal fat ultrasound parameters were compared across groups using one-way ANOVA with post-hoc analysis. ROC analysis identified sex-specific cut-off points for discriminating moderate from severe malnutrition.

Results: A total of 334 patients were included (64.3±11.6 years; 55.1% male). Disease stage II was the most frequent (35.9%). Based on GLIM criteria: 50.5% well-nourished, 39% moderate and 10.6% severe malnutrition.

Fat mass by BIVA was 22.52±8.83, 19.72±8.28, and 11.64±7.68 kg in well-nourished, moderately malnourished, and severely malnourished patients, respectively (p<0.001). Total abdominal fat by ultrasound was 1.95±0.93, 1.61±0.68, and 1.20±0.61 cm, and preperitoneal fat was 0.75±0.43, 0.71±0.42, and 0.42±0.26 cm, respectively (both p<0.001).

To discriminate between moderate and severe malnutrition, ROC analysis identified significant cut-off points for fat mass in men (≤11.6 kg; AUC 0.735; p=0.004) and women (≤15 kg; AUC 0.822; p<0.001), and for US preperitoneal fat in women (≤0.455 cm; AUC 0.740; p<0.001).

Conclusion: Fat mass assessed by BIVA and ultrasound is associated with nutritional status in ALS and may be useful for nutritional diagnosis and monitoring

Disclosure of Interest: M. De Damas Medina Grant / Research Support from: This study received financial support from Persan Farma. The authors declare no other conflicts of interest., A. Segarra Balao: None declared, M. I. Rebollo Pérez: None declared, S. Quintana Arroyo: None declared, F. J. Vílchez López: None declared