PP124 - PERSONALIZED NUTRITION THERAPY IN MENOPAUSAL WOMEN: EFFECTS ON CARDIOMETABOLIC RISK MARKERS

PP124

PERSONALIZED NUTRITION THERAPY IN MENOPAUSAL WOMEN: EFFECTS ON CARDIOMETABOLIC RISK MARKERS

A. Šeta^1,2,*

¹Internal Medicine, SSST University, ²Internal Medicine, Unimed Polyclinic, Sarajevo, Bosnia and Herzegovina

Rationale: Menopause is associated with adverse changes in body composition and cardiometabolic risk. We investigated whether a structured personalized nutrition intervention reduces cardiovascular risk markers compared with standard dietary advice in postmenopausal women.

Methods: In this 6-month prospective controlled study, 124 postmenopausal women (age 48–62 years) with ≥1 cardiometabolic risk factor were allocated to personalized nutrition therapy (PN, n=62) or standard advice (SA, n=62). The PN group received individualized dietary plans delivered through a digital nutrition platform (Nutriseta®), including tailored energy targets, protein intake of 1.2–1.4 g/kg/day, Mediterranean-style dietary pattern, fiber ≥30 g/day, and omega-3 fatty acids (1 g/day). The SA group received general healthy eating recommendations. Primary outcomes were changes in low-density lipoprotein cholesterol (LDL-C) and homeostasis model assessment of insulin resistance (HOMA-IR). Secondary outcomes included body fat percentage and high-sensitivity C-reactive protein (hs-CRP). Significance was set at p<0.05.

Results: At 6 months, the PN group showed greater reductions in LDL-C (−18.4±22.1 vs −6.2±19.5 mg/dL; p=0.004) and HOMA-IR (−0.9±1.3 vs −0.2±1.1; p=0.01) compared with SA. Body fat percentage decreased by −3.1±2.8% in PN vs −1.0±2.5% in SA (p=0.002). hs-CRP decreased significantly in PN (−0.8±1.4 mg/L) compared with SA (−0.2±1.2 mg/L; p=0.03). No serious adverse events were reported.

Conclusion: Personalized nutrition therapy delivered via a structured digital platform significantly improved lipid profile, insulin resistance, body composition, and inflammatory markers compared with standard advice. These findings support the integration of individualized digital nutrition strategies into cardiometabolic risk management during menopause.

Disclosure of Interest: None declared