O068 - PREDICTIVE VALIDITY OF GLOBAL LEADERSHIP INITIATIVE ON MALNUTRITION (GLIM) CRITERIA USING DIFFERENT PHENOTYPIC COMBINATIONS IN HOSPITALIZED PATIENTS WITH EXCESS BODY WEIGHT

O068

PREDICTIVE VALIDITY OF GLOBAL LEADERSHIP INITIATIVE ON MALNUTRITION (GLIM) CRITERIA USING DIFFERENT PHENOTYPIC COMBINATIONS IN HOSPITALIZED PATIENTS WITH EXCESS BODY WEIGHT

V. S. Chites^1,*, J. A. D. M. Costa², G. B. D. A. E. Silva³, A. K. Ramos⁴, F. M. Silva⁵, J. C. de Almeida^6,7

¹Medical Sciences Graduate Program in Endocrinology, ²Nutrition Food and Health Graduate Program, Universidade Federal do Rio Grande do Sul, Porto Alegre, ³Multiprofessional Residency Program in Family Health, Universidade Federal de Santa Catarina, Araranguá, ⁴Multiprofessional Health Residency Program in Oncology and Palliative Care, Hospital de Clínicas de Porto Alegre, ⁵Nutrition Department, Universidade Federal de Ciências da Saúde de Porto Alegre, ⁶Nutrition Department, Universidade Federal do Rio Grande do Sul, ⁷Nutrition and Dietetic Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil

Rationale: The GLIM criteria include muscle mass (MM) assessment, which can be estimated by calf circumference (CC) or mid-upper arm circumference (MUAC). In individuals with excess body weight, CC must be adjusted for body mass index (BMI) to account for adiposity. This study evaluated the predictive validity of GLIM criteria in hospitalized patients with excess body weight, using different phenotypic combinations based on anthropometric indicators of MM.

Methods: Prospective cohort with adults and older adults with BMI ≥25 and ≥27 kg/m², respectively. GLIM criteria were applied within 72h of admission. CC was BMI-adjusted (−3, −7, and −12 cm for BMI 25–29.9, 30–39.9, and ≥40 kg/m², respectively). Reduced MM was defined as CC ≤33 cm for females, ≤34 cm for males, or MUAC <90% adequacy. Phenotypic combinations tested: weight loss (WL) or low CC-BMI; WL or low MUAC; and WL or low CC-BMI or MUAC. Etiologic criteria included reduced food intake/assimilation or inflammation related to acute/chronic disease. Logistic regression explored the associations with prolonged stay (≥7 days), readmission, and six-month mortality.

Results: Of 475 patients (mean age 56 ± 14 years; 52.4% female; BMI 31.7 ± 4.4 kg/m²), 85% were surgical and 23% had cancer. Prevalence of undernutrition by GLIM was 49.6% (WL or low CC-BMI), 14.0% (WL or low MUAC), and 50.0% (WL or low CC-BMI or low MUAC). Only the GLIM approach using WL or low MUAC was independently associated with prolonged stay (odds ratio [OR] 2.4, 95% confidence interval [CI] 1.4–4.2) and hospital readmission (OR 3.3, 95%CI 1.8–5.9). No combination was linked to six-month mortality.

Conclusion: Among patients with excess body weight, the GLIM combination including MUAC as MM indicator showed better predictive validity, as it was associated with prolonged hospital stays and readmission.

Disclosure of Interest: None declared