PT41 - DIETARY INDEX FOR GUT MICROBIOTA, PHYSICAL ACTIVITY IN RELATION TO MORTALITY

PT41

DIETARY INDEX FOR GUT MICROBIOTA, PHYSICAL ACTIVITY IN RELATION TO MORTALITY

J. Zhu^1,*, Q. Lyu^1,2

¹First affiliated hospital of zhengzhou university, ²School of Public Health, Zhengzhou University, Zhengzhou, China

Rationale: To address the unexplored relationship between diet, gut microbiota, and mortality, this study examined the association between the Dietary Index for Gut Microbiota (DI-GM) and mortality risk, and the potential modifying role of physical activity (PA).

Methods: We analyzed data from 22,205 eligible adults in the U.S. National Health and Nutrition Examination Survey (NHANES). DI-GM scores were calculated based on 14 food components associated with gut health. PA levels were assessed using the Global Physical Activity Questionnaire (GPAQ), with total activity calculated in metabolic equivalent (MET) values. Cox proportional hazards regression models were employed to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) to evaluate both the independent and joint associations between DI-GM, PA, and mortality.

Results: During a median follow-up of 6.75 years, 1,454 all-cause deaths occurred. Compared to participants in the lowest DI-GM quartile, those in the highest quartile had a lower risk of all-cause mortality (HR = 0.82, 95% CI: 0.70–0.96). Regarding PA, middle-intensity and high-intensity PA were associated with 10% and 19% reductions in mortality risk, respectively, compared to low-intensity PA (HR = 0.90, 95% CI: 0.82–0.98; HR = 0.81, 95% CI: 0.69–0.93). Participants with both the highest DI-GM scores and high-intensity PA exhibited a 26% decreased risk of mortality (HR = 0.74, 95% CI: 0.56–0.98) compared to those with the lowest DI-GM quartile and low-intensity PA. Additionally, higher DI-GM scores and more intense PA were associated with lower risks of heart disease mortality.

Conclusion: This study demonstrates the independent and joint benefits of a gut microbiota-promoting diet and PA in reducing mortality risk. These findings highlight the importance of incorporating both dietary and PA interventions in public health strategies aimed at improving longevity.

Disclosure of Interest: None declared