PD574 - THERAPEUTIC LIFE STYLE CHANGES (TLC) AND BARIATRIC SURGERY DECREASE THE PREVALENCE OF FOOD ADDICTION (FA) IN PATIENTS WITH SEVERE OBESITY: AN OBSERVATIONAL RETROSPECTIVE LONGITUDINAL STUDY

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PD574

THERAPEUTIC LIFE STYLE CHANGES (TLC) AND BARIATRIC SURGERY DECREASE THE PREVALENCE OF FOOD ADDICTION (FA) IN PATIENTS WITH SEVERE OBESITY: AN OBSERVATIONAL RETROSPECTIVE LONGITUDINAL STUDY

S. Eon1, M. Guiho1, E. Rageul1, M. Barrallier1, R. Pflaum1, H. Pisaroni1, A. Durous1, M. Som1, R. Thibault1,1,2,2,*

1Endocrinology-Diabetology-Nutrition, CHU Rennes, 2Nutrition, Metabolisms and Cancer (NuMeCan), INRAE, INSERM, Univ Rennes, Rennes, France

 

Rationale: FA is frequent in patients with obesity but its evolution is poorly known during obesity therapy. Aims: to evaluate FA prevalence evolution after a 6-month program of TLC in patients with severe obesity (primary) and after bariatric surgery (secondary); identify predictive factors for FA improvement or remission (secondary).

Methods: We conducted an 8.5-year (2016-2025) observational, retrospective, longitudinal study in patients with severe obesity enrolled in a standardized 6-month TLC program at our reference centre. Collected data at different time points: Yale Food Addiction Scale (YFAS) 2.0 scores, anthropometry, bioclinical, behavior. Statistics: multivariate logistic regression.

Results: N=587 patients (82% women, age, 42.2 ± 11.7 yr, body mass index, 42.9±5.8) completed the baseline YFAS 2.0. FA prevalence: 47.5 % (279/587), severe FA, 68.1 %. At 6-month program end, FA prevalence: 15.8 % (18/127). Favorable FA evolution associated with earlier obesity onset (odds ratio (OR)=0.94 [95% confidence interval, 0.89–0.99], P=0.03), lower alkaline phosphatase plasma concentrations (OR=0.98 [0.96-1.00], P=0.04), absence of metabolic syndrome (OR=0.25 [0.10-0.62], P=0.003). 11 month (median) after bariatric surgery, FA prevalence dropped from 30.6 % (27/88) to 5.7 % (5/88). FA improvement or remission after surgery associated with: being single (OR=5.96 [1.18-30.1], P=0.03), tachyphagia (OR=8.07 [1.79-36.3], P=0.007), sleeve gastrectomy (OR=0.06 [0.01-0.55], P=0.01), higher ALAT (OR=1.04 [1.01-1.08], P=0.02) and triglyceride  (OR=4.01 [1.18-13.6], P=0.03) plasma concentrations. 

Conclusion: FA decreases markedly in patients with severe obesity after TLC and bariatric surgery. It confirms the high prevalence of FA and highlights the need for personalized nutrition approaches to sustain behavioral changes.

Disclosure of Interest: None declared