P1046 - IMPACT OF IMMUNONUTRITION IN PREHABILITATION FOR GASTRO-ESOPHAGEAL SURGERY: A RETROSPECTIVE COHORT STUDY

P1046

IMPACT OF IMMUNONUTRITION IN PREHABILITATION FOR GASTRO-ESOPHAGEAL SURGERY: A RETROSPECTIVE COHORT STUDY

E. Finizio^1,*

¹University of Florence, Florence, Italy

Rationale: Prehabilitation is an emerging strategy to optimize a patient’s status before major surgery. This study aims to assess the impact of immunonutrition (IMN) as part of Prehabilitation in patients undergoing gastro-esophageal surgery.

Methods: In this retrospective cohort study, we analyzed data from 41 patients, involved in a multimodal prehabilitative program, divided into two groups: those receiving IMN before surgery (n=21) and those not (n=20). Both groups also recevied exercise, nutritional, medical and socio-physicological support. Assessments were conducted at three points: T0 (start of Prehabilitation), T1 (one week before surgery), and T2 (30 days post-surgery). Statistical comparisons of variables between the two groups were performed using the T-test and Wilcoxon rank-sum test. Normality was assessed via QQ-plots and and/or the Shapiro-Wilk normality test. Homogeneity of variance was evaluated with Levene's test. Group differences in binomial variables were assessed using Fisher’s exact test. Statistical significance was set at p≤0.05.

Results: The two groups were comparable in terms of age, gender and type of surgery. No significant differences were found between the two groups for biochemical parameters, length of stay, or incidence of complications. Between T0 and T2, differences in variation of anthropometry and body composition were observed. Specifically, the decrease in appendicular skeletal muscle mass index (ASMMI) (p=0.04224), body weight (p=0.01815), and BMI (p=0.006242) was more pronounced in the group not treated with IMN. The same trend was observed for fat free mass index, grip strenght and phase angle, though without statistical significance.

Conclusion: Prehabilitation with preoperative IMN appears to better preserve body composition and nutritional status, suggesting a potential enhancement in the overall efficacy of Prehabilitation before gastro-esophageal surgery.

Disclosure of Interest: None declared