P952 - PRE-TRANSPLANT DIETARY FIBRE INTAKE IN IBS-D AND IBS-M PATIENTS: INSIGHTS FROM THE MISCEAT STUDY

P952

PRE-TRANSPLANT DIETARY FIBRE INTAKE IN IBS-D AND IBS-M PATIENTS: INSIGHTS FROM THE MISCEAT STUDY

J. Vejmelka^1,*, M. Dusova², M. Kollerova², P. Kohout¹

¹Department of Internal Medicine and Clinical Nutrition Center, Third Faculty of Medicine, Charles University and Thomayer University Hospital , ²Nutrition and Dietetics Center, Thomayer University Hospital, Prague , Czech Republic

 

Rationale: IBS treatment is complex, with dietary interventions playing a key role. In the MISCEAT study, we evaluated fibre intake in IBS-D and IBS-M patients before faecal microbiota transplantation (FMT) and explored its potential impact on symptom management.

 

 

 

Methods: We assessed daily fibre intake in 17 IBS-D/M patients (11 males, 6 females, age 22–63) enrolled in the MISCEAT trial (NCT04899869)¹. Participants followed the protocol and maintained their usual diet. One week prior to FMT, patients recorded their dietary intake in the food tracking application kaloricketabulky.cz, which provided data for fibre intake analysis. Baseline IBS Severity Scoring System (IBS-SSS) scores were recorded.

 

 

 

 

Results: Fibre intake ranged from 3.3 to 49.4 grams, with a median of 17.3 grams and a mean of 19.4 grams (SD = 11.29). The interquartile range (IQR) was 13.2 to 22.0 grams, showing variability among patients. IBS-SSS scores ranged from 25.0 to 405.0, with a median of 270.0 and a mean of 245.3 (SD = 101.57, IQR = 205.0–325.0). The Pearson correlation between fibre intake and IBS-SSS was –0.144 (p = 0.580), indicating a weak, non-significant negative correlation.

 

 

 

 

 

Conclusion: We found a weak, non-significant negative correlation between fibre intake and IBS-SSS, suggesting further investigation is needed. Factors like fibre type, gut microbiota, and patient adherence may have influenced the results. Despite this, the role of dietary fibre in IBS warrants further research. Larger studies with microbiome profiling are needed to clarify its impact. Additionally, studies on specific fibre types and IBS subgroups could help identify patients most likely to benefit from optimising their fibre intake.

 

 

References: Hurych J, Vejmelka J, Hlinakova L, Kramna L, Larionov V, Kulich M, Cinek O, Kohout P. Protocol for faecal microbiota transplantation in irritable bowel syndrome: the MISCEAT study. BMJ Open. 2022 Jun 27;12(6):e056594.

 

 

 

Disclosure of Interest: None declared