PD527 - INFECTIOUS ENDOCARDITIS AND OSTEOMYELITIS IN PATIENTS WITHCHRONIC INTESTINAL FAILURE: A FIVE-YEAR OBSERVATIONAL STUDY

PD527

INFECTIOUS ENDOCARDITIS AND OSTEOMYELITIS IN PATIENTS WITH

CHRONIC INTESTINAL FAILURE: A FIVE-YEAR OBSERVATIONAL STUDY

 

K. Isho^1,*, I. nielsen¹, A. Larsen¹, J. Kristensen¹, F. Odgaard¹, H. rasmussen¹, M. Holst¹, C. Hvas², J. Fassov², C. Rud², L. Vinterjensen¹

¹Dept of Medical Gastroenterology, Aalborg University Hospital, Aalborg, ²Dept of Medical Gastroenterology, Aarhus University Hospital, Aarhus, Denmark

 

Rationale: Chronic intestinal failure (CIF) is a severe condition with impaired demanding home parenteral nutrition (HPN). Catheters used to administere HPN

ican be infected, so-called catheter-related bloodstream infections (CRBSI). Rarely CRBSI

develop into metastatic infections such as infectious endocarditis (IE) and os-

teomyelitis (OM). We investigated the clinical course, preceding factors, diagnosis, management, and morbidity and

mortality the patients IE or OM.

Methods: We performed this retrospective cohort study of our patients with CIF from 1st of January 2021 to 17th of February 2026.

Data were collected from medical records of patients from the Centres of Nutrition and Intestinal Diseases at

Aalborg and Aarhus University Hospitals. Data were analysed in StataMP with Fisher’s

exact test, logistic regression, multiple logistic regression, Kruskal-Wallis test, Mann-

Whitney U test, and Kaplan-Meier survival analysis.

 

Results: Of the 171 patients assessed, 8 cases of IE and 13 cases of OM were identified.

There were no significant differences in nutritional status, catheter characteristics, clinical char-

acteristics, or outcome between patients with IE and OM. However, patients with IE and

OM had significantly higher mortality rates than patients with HPN without infection.

Most cases of IE and OM were caused by Staphylococcus epidermidis and unspecified

coagulase-negative staphylococci.

Conclusion: This study found that patients with IE and OM had significantly increased odds of dying

within the study period when compared with patients with HPN without infection. This

was despite finding no significant differences in nutritional status, catheter characteristics,

clinical characteristics, or outcome between the two groups. Furthermore, Staphylococcus

epidermidis and coagulase-negative staphylococci were identified as the most frequent

causative microorganisms of IE and OM.

Disclosure of Interest: None declared