PD911 - BISPHENOL EXPOSURE AND ITS ROLE IN THE RELATIONSHIP BETWEEN EXCESS WEIGHT AND COGNITIVE FUNCTION IN CHILDREN

PD911

BISPHENOL EXPOSURE AND ITS ROLE IN THE RELATIONSHIP BETWEEN EXCESS WEIGHT AND COGNITIVE FUNCTION IN CHILDREN

P. G. Palacios^1,2,*, C. M. Sánchez^1,2,3, M. V. A. F. de Bobadilla⁴, A. R. Velasco^1,3,5, A. Z. Gómez^3,5,6 on behalf of ExpoDiet

¹Department of Nutrition and Food Sciences, Faculty of Pharmacy, University of Granada, 18071 Granada, Spain., University of Granada, ²Institute of Nutrition and Food Technology (INYTA), Biomedical Research Centre (CIBM), University of Granada, 18100 Granada, Spain., ³“José Mataix Verdú” Institute of Nutrition and Food Technology (INYTA), Biomedical Research Centre (CIBM), University of Granada, 18100 Granada, Spain., ⁴Maracena Health Center, Andalusian Health Service, Granada, Spain., ⁵Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain., ⁶Department of Analytical Chemistry, University of Granada, 18071 Granada, Spain., University of Granada, Granada, Spain

Rationale: Bisphenols are chemical compounds widely used in the manufacture of polycarbonate plastics and epoxy resins found in numerous everyday products, particularly in materials that come into contact with food. These compounds can act as endocrine disruptors, raising concerns about their potential effects on health, especially during sensitive developmental stages such as childhood.
The aim of this study was to assess bisphenol exposure in a pediatric population and to analyze its possible role in the association with excess weight and cognitive function.

Methods: A study was conducted in children aged 6 to 12 years from the province of Granada (Spain). Biological samples of urine and hair were collected to determine bisphenol exposure through biomonitoring. Concentrations of different bisphenols were analyzed using ultra-high-performance liquid chromatography coupled with tandem mass spectrometry (UHPLC-MS/MS). Cognitive function was assessed using the Wechsler Intelligence Scale for Children (WISC-V).

Results: Bisphenols were detected in a high proportion of samples, indicating widespread exposure in the studied pediatric population. Excess weight was associated with poorer performance in several cognitive domains, particularly verbal comprehension, visuospatial skills, fluid reasoning, and working memory. Mediation analyses suggest that BPA exposure may play a role in the relationship between excess weight and certain cognitive functions.

Conclusion: Exposure to bisphenols may strengthen the negative association between excess weight and cognitive function in children. In particular, BPA may act as a potential mediator in this relationship.

Disclosure of Interest: None declared