P174 - IMPROVING NUTRITIONAL STABILITY, PROTEIN SYNTHESIS, AND MINERAL ABSORPTION IN THE ELDERLY : A SYNERGISTIC APPROACH OF INTERMITTENT NUTRIENT ADMINISTRATION VIA POST-PYLORIC FEEDING COMBINED WITH A DILUTED LIQUID FORMULA FERMENTED BY LACTIC ACID BACTERIA

P174

IMPROVING NUTRITIONAL STABILITY, PROTEIN SYNTHESIS, AND MINERAL ABSORPTION IN THE ELDERLY : A SYNERGISTIC APPROACH OF INTERMITTENT NUTRIENT ADMINISTRATION VIA POST-PYLORIC FEEDING COMBINED WITH A DILUTED LIQUID FORMULA FERMENTED BY LACTIC ACID BACTERIA

M. Sakisaka^1,*

¹surgery, Sakisaka Hospital, Kumamoto, Japan

Rationale: Post-pyloric feeding has been reported to reduce enteral tube feeding-related complication in the acute management of ICU patients. However, its effectiveness as a routine long-term nutritional route in chronic care have not been thoroughly evaluated. Furthermore, whether it maintains nutrient and trace element absorption remains unclear.

Methods: Post-pyloric feeding was administered for six months in elderly patients. The incidence of complications, such as aspiration pneumonia, vomiting, as well as the continuity of nutrition, was assessed (n=17). To identify the optimal nutritional formula for long-term post-pyloric feeding, the digestibility and absorption of nutrients and trace elements were evaluated using a novel diluted fermented liquid formula over a 12-month period (n=8).

Results: In the management of post-pyloric feeding, the frequency of aspiration pneumonia and vomiting was significantly reduced, and the fasting period was significantly shortened. Long-term post-pyloric feeding with the diluted fermented formula resulted in a significant increase in serum albumin, calcium, and copper concentrations. Additionally, the CONUT score showed significant improvement.

Conclusion: In the long-term nutritional management of elderly patients, post-pyloric feeding stabilized nutrient administration and reduced enteral tube feeding-related complications. This study also revealed, for the first time, that the administration of a diluted fermented liquid formula via the duodenum improves nutrient digestibility, protein synthesis, and mineral absorption.

References: Alkhawaja S, et al. Cochrane Database Syst Rev. 2015 Aug 4;2015(8):CD008875.

Camilleri M, et al. Clinical Guideline: Management of Gastroparesis. Am J Gastroenterol. 2013 Jan;108(1):18-37; quiz 38

Disclosure of Interest: None declared