LB059 - THE PREDICTIVE FACTOR OF PROGNOSTIC NUTRITIONAL INDEX ON GRAFT FUNCTION AFTER KIDNEY TRANSPLANTATION

LB059

THE PREDICTIVE FACTOR OF PROGNOSTIC NUTRITIONAL INDEX ON GRAFT FUNCTION AFTER KIDNEY TRANSPLANTATION

H. Lee^1,*, S. Yoo²

¹Surgery, Chonnam National University Medical School, ²College of Nursing, Chonnam National University, Gwangju, Korea, Republic Of

Rationale: In kidney transplant recipients, graft outcomes are influenced by various factors, among which nutritional status plays a critical role in post-transplant complications and survival. The Prognostic Nutritional Index (PNI), which reflects both nutritional and immune status, has been utilized as a prognostic marker in various clinical settings. This study aimed to evaluate the predictive value of PNI on graft function and patient survival following kidney transplantation.

Methods: We conducted a retrospective cohort study involving 326 patients who underwent kidney transplantation between January 2014 and March2023. PNI was calculated using baseline serum albumin levels and peripheral blood lymphocyte counts at admission. Demographic characteristics, clinical parameters, estimated glomerular filtration rate (eGFR) and parenchymal thickness were evaluated.  The primary endpoints were delayed graft function(DGF) at 1 week and patient survival within 1 year post-transplant. Multiple logistic regression analysis was used to identify predictors.

Results: Of the 326 patients, male were 62.0%, and the mean(±SD) age was 49.5(±11.4). There were 25(7.7%) patients who developed DGF 1 week post-transplant, and the 1-year survival rate was 96.9%. Even after adjusting for diabetes status, PNI(OR[95% CI] = 1.13[1.03~1.24], p-value=.009) remained a significant predictor of 1-week DGF, along with age(OR[95% CI] = 1.05[1.01~1.11], p-value=.031). The cut-off value of PNI that best predicted DGF through the Youden index of the receiver-operating characteristic(ROC) curve analysis was 42.11875 score. Baseline PNI was not statidtically associated with 1-year survival(p=.433).

Conclusion: PNI is a valuable predictive marker for 1-week graft function after kidney transplatation . Optimizing nutritional and inflammatory status before and after transplantation may contribute to improved outcomes. Further multicenter studies are warranted to establish optimal PNI cut-off values and validate its clinical applicability.

Disclosure of Interest: None declared