P145 - PLASMA SELENIUM LEVELS IN CRITICALLY ILL PATIENTS WITH SHOCK SEPSIS RECEIVING CONTINUOUS RENAL REPLACEMENT THERAPY

P145

PLASMA SELENIUM LEVELS IN CRITICALLY ILL PATIENTS WITH SHOCK SEPSIS RECEIVING CONTINUOUS RENAL REPLACEMENT THERAPY

T. P. H. Nghiem^1,*, T. H. G. Bui¹, T. H. Hoang², Q. T. Dang¹, T. T. Tran¹, T. T. Bui³, T. T. H. Uong⁴, T. T. H. Hoang⁵, N. S. Do¹

¹Bach Mai hospital, Center for Critical Care Medicine, ²Saint Paul General hospital, Department of Biochemistry, Ha Noi, ³Thai Binh Provincial general hospital, Thai Binh, ⁴Bach Mai hospital, Department of Biochemistry, ⁵Vietnam Academy of Science and Technology, Institute of Chemistry, Ha Noi, Viet Nam

Rationale: Selenium is essential for patients with shock sepsis, and its levels may decline during continuous renal replacement therapy (CRRT). This study aims to assess selenium status before and after CRRT in critically ill patients having shock sepsis.

Methods: A prospective observational study was conducted involving medical ICU patients diagnosed with shock sepsis who received CRRT. Selenium levels were measured before and after CRRT using inductively coupled plasma mass spectrometry (ICP-MS).

Results: Thirty one patients were enrolled, of which 74,2% were male. The causes of shock sepsis were pneumonia (51.6%), septicemia (22.6%), gastrointestinal infection (22.6%), urinary tract infection (3.2%). Before CRRT, the APACHE II score was 18,4 ± 6.0, and the SOFA score was 10.7 ± 2.5. After CRRT, the APACHE II score was 15.5 ± 6.2, and the SOFA score was 10.2 ± 4.3. Selenium deficiency was observed in 37.8% of patients before CRRT and 67.7% after CRRT. The overall mortality rate was 58.1%.The median time for CRRT was 2.3 (1.7-4) days. The plasma selenium levels pre- and post-CRRT showed a significant difference (80.59 (52.95-91.28) versus 62.00 (42.13-76.63) µg/L; p=0.023). There was no correlation between selenium levels and APACHE II or SOFA scores at the start or end of CRRT. Additionally, mortality rates did not significantly differ between patients with selenium deficiency and those without (p > 0.05).

Conclusion: Patients with shock sepsis show decreased plasma selenium levels during CRRT. Further studies should be performed to evaluate the impact of selenium deficiency in this patient population.

References: McArthur J. The Role of Selenium in Sepsis. TOINFJ. 2011;4(1):115-119. doi:10.2174/1875041901104010115

Disclosure of Interest: None declared