P242 - COFFEE CONSUMPTION AND CELLULAR AGING: A SYSTEMATIC REVIEW ON TELOMERE LENGTH

P242

COFFEE CONSUMPTION AND CELLULAR AGING: A SYSTEMATIC REVIEW ON TELOMERE LENGTH

P. D. Wirayanti^1,*, N. K. Sumartini¹, I. P. P. Ratha¹

¹Department of Clinical nutrition , Udayana University, Denpasar, Indonesia

Rationale: Coffee's active ingredients might lower oxidative stress and improve DNA integrity. This study aimed to explore the association between coffee consumption and cellular aging through Telomer Length.

Methods: This systematic review followed PRISMA guidelines and evaluated the impact of coffee consumption on Telomer Length. An extensive database search was conducted on February 26, 2024, across three databases: PubMed, ScienceDirect, and the Cochrane Library. The search strategy incorporated MeSH terms such as “Coffee”, “Telomere”, “Aging”, “Cell Aging”, “Oxidative Stress”, “Biomarkers”, and “Outcomes”. Studies were screened using PICOS criteria, quality-assessed with the Newcastle-Ottawa Scale (NOS) for non-randomized studies and the Risk of Bias (ROB) tool for RCT

Results: A total of 893 studies were obtained, and five studies were included in this study. Three high-quality observational studies reported a positive association between coffee consumption and longer TL. One study found no significant overall association but noted benefits in specific subgroups. Conversely, observed a negative association between instant coffee and TL in both observational and MR analyses, suggesting a possible causal effect.

Conclusion: Evidence on the impact of coffee on telomere length is mixed. While most observational studies suggest beneficial effects, MR analysis indicates potential harm from instant coffee. Further longitudinal and experimental studies are needed to clarify these relationships.

Disclosure of Interest: None declared