PD753 - MICRONUTRIENT INTAKE AND DEFICIENCY PATTERNS IN MULTIPLE MYELOMA PATIENTS

PD753

MICRONUTRIENT INTAKE AND DEFICIENCY PATTERNS IN MULTIPLE MYELOMA PATIENTS

L. S. Sester^1,*, A. K. Gambihler¹, M.-S. Raab¹, C. K. Stein-Thoeringer²

¹Internal Medicine V, University Hospital Heidelberg, Heidelberg, ²Internal Medecine I, Clinic Tübingen, Tuebingen, Germany

Rationale: Nutritional status may influence treatment outcomes in multiple myeloma (MM), yet systematic data on dietary intake in these patients are limited.

Methods: Dietary intake of 62 newly diagnosed MM patients was assessed using a validated food frequency questionnaire and analyzed with DGExpert 2.0. Micro- and Macronutrient intake was compared to German Nutrition Society (DGE) recommendations (1).

Results: Lowest intakes were observed for vitamin D and fluoride. Moderate intakes were common for iodine, calcium, vitamin b5, potassium, zinc and ion. In contrast several nutrients exceed recommended intake, including chloride and sodium (Fig.1A). Macronutrient intake was largely adequate according to DGE recommendations, while fiber intake was consistently below recommendations (Fig. 1B). However, current guidelines suggest higher protein intake targets for cancer patients (2), indicating that protein intake in this cohort may still be suboptimal. Importantly, populations at increased risk for insufficient vitamin D synthesis include elderly, chronically ill and mobility-restricted individuals – groups that overlap with MM patients – highlighting the clinical relevance of vitamin D supplementation in this population.

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Conclusion: MM patients display a distinct pattern of micronutrient imbalance characterized by simultaneous deficiencies and excesses. While macronutrient intake appears largely adequate based on general population recommendations, it may not meet the higher nutritional requirements of cancer patients, particularly regarding protein intake. These findings highlight the need for structured nutritional assessment in MM, while carefully considering disease-specific risks such as hypercalcemia. Integration of individualized dietary counseling into clinical care may represent a strategy to improve patient outcomes.

References: (1) www.dge.de/wissenschaft/referenzwerte-tool

(2) Klinische Ernährung in der Onkologie S3-Guideline

Disclosure of Interest: None declared