P316 - ANALYSIS OF INFLAMMATORY MARKERS IN PROGRESSION-FREE SURVIVAL AND OVERALL SURVIVAL IN COLORECTAL CANCER

P316

ANALYSIS OF INFLAMMATORY MARKERS IN PROGRESSION-FREE SURVIVAL AND OVERALL SURVIVAL IN COLORECTAL CANCER

E. Madureira^1,*, L. Moreira², J. Machado-Firmino^2,3,4

¹Nutrition, ULS São João, ²FMUP, ³ISPUP, Porto, ⁴Universidade de Aveiro, Aveiro, Portugal

Rationale: Identify prognostic factors in cancer patients is extremely important in the clinical set. Our aim is to test whether inflammatory indices: Systemic Immunoinflammation Index (SII), Nutritional Prognostic Index (PNI), Advanced Pulmonary Inflammation Index (ALI), Platelet-Lymphocyte Ratio (PLR), Neutrophil-Lymphocyte Ratio (NLR), can predict progression-free survival (PFS) and overall survival (OS) in patients with Colorectal Cancer (CRC). 

Methods: A retrospective study was conducted with adult patients diagnosed with CRC between 2009 and 2023. Data to determine the indices were collected every three months from diagnosis up to five years. We use the data collected 1 to 4 months before the progression and the data from the last nutrition consultation for those who did not progress. The analysis of PFS and OS was performed using the Kaplan-Meier curve (groups divided into low and high). Cox regression was used to determine the risk (HR) of disease progression and death. 

Results: We evaluated 214 patients. For ALI and PNI, the low group had a lower survival when compared to the high group. For the other markers, the opposite occurred. In the survival curve for OS, there was a significant difference only in PNI (p=0.007), at the last nutrition consultation. From the indices before progression only PNI had significant results (p=0.023) [HR:0.953 CI95% 0.915-0.993]. From the indices obtained at the first nutritional consultation, three showed significances: SII (p=0.008) [HR: 1.000 CI95% 1.000-1.001]; PLR (p=0.014) [HR: 0.995 CI95% 0.991-0.999] and PNI (p=0.022) [HR: 0.951 CI95% 0.912-0.993]. 

Conclusion: ALI, SII and PNI can be good prognostic factors in patients with CRC, since PNI showed significant differences in almost all tests, ALI was associated with disease progression and SII was associated with death. T

Disclosure of Interest: None declared