P239 - ASSESSMENT OF INFECTIOUS AND NONINFECTIOUS CATHETER COMPLICATIONS IN PEDIATRIC PATIENTS RECEIVING HOME PARENTERAL NUTRITION

P239

ASSESSMENT OF INFECTIOUS AND NONINFECTIOUS CATHETER COMPLICATIONS IN PEDIATRIC PATIENTS RECEIVING HOME PARENTERAL NUTRITION

M. A. Madkoor^1,* on behalf of Dr. Noura Albunian and Dr. Bader alsleem

¹Jazan Health cluster, Pharmacy Department , King Fahad Central hospital, Jazan, Saudi Arabia, Saudi Arabia

Rationale: Although patients receiving HPN are vulnerable to infectious and noninfectious complications, little is known about the incidence and nature of these complications. 

Methods: this retrospective observational study was conducted in a tertiary care hospital over four months. We included all patients with intestinal failure who received HPN between 01 Jan 2018 and 31 Aug 2021. Patients who were newly HPN users who had previously documented infections, or were on antibiotics before starting HPN were excluded. Continuous and categorical data were given as the mean ± standard deviation, median (interquartile range), or number (percentage), wherever appropriate. Poisson regression was used for Catheter day rate /patient. A P‐value of < .05 was considered statistically significant.  The final database was entered into the Statistical Package for the Social Sciences (SPSS) version 26 for statistical analysis.

Results: Of the 24 patients included in the study, 14 (58.3%) were females. The mean age was 6.6±3.4 years.  The infectious and noninfectious complications rate was 87.5% and 8.3%, respectively. The analysis of infectious complications per catheter day showed 4.9 events per 1000 catheter days. Most patients (87.5%) used one-lumen catheters (BROVIAC). The mean length of stay in the hospital was 20.3±16.5 days.  The findings of this study showed that 22.5% and 17.7% of the infections were caused by Staphylococcus Aureus and Staphylococcus Epidermidis, respectively. The most common antibiotic used to treat bacterial infections was vancomycin (46.8%).The proportion of line removal as a result of Catheter-related infection was estimated to be 6 (8.4%). 

Conclusion: Catheter-related infectious complications are extremely common in patients receiving home parenteral nutrition in Saudi Arabia. Most of the infections were caused by Staphylococcus Aureus and Staphylococcus Epidermidis.

Disclosure of Interest: None declared