PP140
HYPOPROTEIN DIET, NUTRITIONAL STATUS AND RENAL FUNCTION IN NON-DIALYSED CHRONIC KIDNEY DISEASE PATIENTS
M. Dias1,*, M. J. Duarte2, S. Velho1, C. Teixeira3, E. Almeida3, S. Silva3
1Dietetic and Nutrition, Local Health Unit Loures-Odivelas, 2Nutrition, Lisbon Lusíadas Hospital, 3Nephrology, Local Health Unit Loures-Odivelas, Lisbon, Portugal
Rationale: Chronic kidney disease (CKD) is a progressive condition associated with declining renal function. Hypoprotein diets (HPD) and very low protein diets (VLPD) supplemented with ketoanalogues (KA) may preserve renal function while preventing malnutrition. This study aimed to evaluate the impact of HPD and VLPD with KA on renal function and nutritional status in pre-dialysis CKD patients.
Methods: This retrospective study included 71 pre-dialysis CKD patients followed in nephrology nutrition hospital consultation. Patients received HPD (0.6–0.8 g/kg/day) or VLPD (0.3–0.5 g/kg/day) with KA supplementation. Age, protein intake, estimated glomerular filtration rate (eGFR), creatinine, urea, body weight and Body Mass Index (BMI) were collected at baseline and after 3–6 months. Data management and analysis were performed using Jamovi software (version 2.6.44). Within the group of patients with HPD, a comparative analysis was performed between those who comply and those who do not comply with the prescribed protein value, using Student's t-test or Mann-Whitney. The correlation between protein intake and renal function parameters at 3–6 months was assessed using Pearson's or Spearman's correlation coefficients.
Results: Older age was associated with lower baseline eGFR (R²=0.088, p=0.012), as expected. Higher protein intake was associated to a significant reduction in eGFR at 6 months (−0.17 mL/min/1.73 m² per gram, p=0.006). VLPD with KA was associated with a slower decline in renal function compared to HPD, without significant changes in weight or BMI.
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Conclusion: Age and adherence to HPD are important determinants of kidney function. Individualized nutritional strategies and close monitoring are essential to renal protection and nutritional status.
Disclosure of Interest: None declared