LB074 - FEMHEALTH: PRECISION NUTRITION IN CLIMACTERIC WOMEN - FACTORS ASSOCIATED WITH SYMPTOM SEVERITY

LB074

FEMHEALTH: PRECISION NUTRITION IN CLIMACTERIC WOMEN - FACTORS ASSOCIATED WITH SYMPTOM SEVERITY

G. X. Bazán^1,*, C. M. Fernández-Díaz^2,3, A. Calvo Madueño², S. Ovalle¹, L. P. Fernández², M. I. Espinosa-Salinas¹, S. Molina Arranz¹, C. Crespo¹, E. Berrueta Navas³, B. Arce-López¹, A. Ochaita Aguado², M. García-Beccaria⁴, M. Quintela-Fandino⁵, J. C. Quintela⁶, S. Cruz-Gil², R. Ramos Ruiz¹, A. Ramírez de Molina^1,2

¹GENYAL Platform, ²Molecular Oncology Group, IMDEA NUTRITION, ³Precision For Health SL, ⁴Biostatistics and Bioinformatics Unit, IMDEA NUTRITION, ⁵Breast Cancer Clinical Research Unit, Centro Nacional de Investigaciones Oncológicas-CNIO, ⁶NATAC BIOTECH, Madrid, Spain

Rationale: Menopause and the climacteric are associated with significant symptomatic variability and changes in quality of life, body composition, metabolism and cardiometabolic risk. In this context, FEMHEALTH, an I+D+i project (CPP2023-010803) funded by MICIU/AEI, integrates clinical, nutritional and biological variables to identify profiles associated with symptom severity and guide future non-hormonal precision nutrition strategies.

Methods: A cross-sectional observational study (n= 133 women; mean age 44.9 ± 12.2; ethics approval: IMD PI-076) was conducted at the GENYAL Clinical Trials Platform of IMDEA Nutrition. Volunteers were classified according to reproductive status and the severity of menopause-related symptoms using the Menopause-Specific Quality of Life questionnaire (MENQOL). Anthropometric and body composition measurements, medical history and lifestyle variables were collected, together with blood, urine and stool samples for the analysis of a comprehensive set of biomarkers (metabolomics, genetics, epigenetics and microbiome).

Results: The descriptive analysis characterized the baseline dataset (clinical, anthropometric, lifestyle and symptomatic profile) of the study population, providing integrated overview of reproductive status, body composition, cardiometabolic related variables, lifestyle factors and climacteric symptom burden across study groups. MENQOL enabled a structured assessment of symptoms burden and quality of life domains, supporting the characterization of participants according to their climacteric symptom profile.

Conclusion: FEMHEALTH will provide essential data for developing precision nutrition strategies aimed at supporting future nutritional, supplementation or microbiome modulation interventions that contribute to improving women’s health and quality of life during the climacteric period.

Disclosure of Interest: None declared