PP027 - WOMEN’S ADHERENCE TO A PLANT-BASED DIET AND INFERTILITY TREATMENT OUTCOMES

PP027

WOMEN’S ADHERENCE TO A PLANT-BASED DIET AND INFERTILITY TREATMENT OUTCOMES

T. Konstantinou^1,*, D. Karayiannis², A. Karachaliou¹, M. Kontogianni¹, N. Yiannakouris¹

¹Department of Nutrition and Dietetics, School of Health Sciences and Education, Εleftheriou Venizelou 70 Street, Harokopio University, 17676 Athens, ²Department of Clinical Nutrition, Evangelismos General Hospital, 10676 Athens, Greece

Rationale: Recent evidence suggests that a healthy diet may improve live birth rates in women undergoing assisted reproductive technologies (ART), although further research is needed. The Plant-Based Dietary Index (PDI) evaluates diet quality through three components: overall plant-based intake (PDI), healthy plant-based intake (hPDI) and unhealthy plant-based intake (uPDI). Greater adherence to a healthy PDI has been linked to lower risk of chronic diseases, but its role in reproductive health has not been studied. This study examined the association between PDI and ART outcomes in subfertile women in Greece.

Methods: The study included 244 non-obese women aged 26-55 years. Dietary intake was assessed using a food frequency questionnaire, from which PDI, hPDI and uPDI scores were calculated. Higher PDI, hPDI and lower uPDI scores indicate better diet quality. Generalized linear models were used to assess associations between score tertiles and ART outcomes, including intermediate measures (embryo quality, fertilization rate) and clinical outcomes (implantation, clinical pregnancy, live birth), after adjusting for confounders.

Results: Among 229 women who underwent embryo transfer, 138 achieved implantation, 104 had a clinical pregnancy and 99 gave live birth. No associations were observed with intermediate outcomes. However, women in the highest hPDI tertile had significantly higher rates of clinical pregnancy (54.2% vs. 29.1%, p=0.005) and live birth (53.0% vs. 25.3%, p=0.001) compared to those in the lowest tertile. In contrast, women in the highest uPDI tertile had lower live birth rates (28.2% vs. 42.5%, p=0.017). Multivariate analyses showed that higher hPDI adherence increased the likelihood of clinical pregnancy [Relative Risk (95% CI): 3.41 (1.42-8.20), p-trend=0.006] and live birth [4.57 (1.85-11.29), p-trend=0.001].

Conclusion: Pretreatment adherence to a healthy plant-based diet is associated with improved ART success.

Disclosure of Interest: None declared