PP088 - MUSCLE ULTRASOUND AND BIOELECTRICAL IMPEDANCE–DERIVED PARAMETERS PREDICT GLIM-DEFINED MALNUTRITION AND MORTALITY IN LUNG CANCER

PP088

MUSCLE ULTRASOUND AND BIOELECTRICAL IMPEDANCE–DERIVED PARAMETERS PREDICT GLIM-DEFINED MALNUTRITION AND MORTALITY IN LUNG CANCER

R. Fernandez Jimenez^1,*, P. Rodríguez de Vera-Gómez², M. D. C. Galindo -Gallardo², A. Carmona-Llanos³, M. T. Zarco-Martín⁴, M. González-Pacheco⁵, F. X. Palmas-Candia⁶, M. D. C. Roque-Cuéllar⁷, A. Muñoz-Garach⁸, C. Muñoz-Jimenez⁹, M. I. Rebollo-Pérez¹⁰, M. L. Fernandez-Soto ⁴, J. M. Garcia-Almeida¹ on behalf of VAL-ONC GROUP

¹Endocrinologia y nutricion, Hospital Universitario Virgen de la Victoria, Málaga, ²Endocrinologia y nutricion, Hospital Universitario Virgen Macarena, Sevilla, ³Endocrinologia y nutricion, Hospital Universitario Virgen de Jerez, Cádiz, ⁴Endocrinologia y nutricion, Hospital Universitario San Cecilio, Granada, ⁵Hospital Universitario Puerta del mar, Cádiz, ⁶Endocrinologia y nutricion, Hospital Universitario Vall d'hebron, Barcelona, ⁷Endocrinologia y nutricion, Hospital Universitario Virgen del Rocio, Sevilla, ⁸Endocrinologia y nutricion, Hospital Universitario Virgen de las Nieves, Granada, ⁹Endocrinologia y nutricion, Hospital Universitario Reina Sofia, Cordoba, ¹⁰Endocrinologia y nutricion, Hospital Universitario Juan Ramon Jimenez, Huelva, Spain

Rationale: Malnutrition is highly prevalent in patients with lung cancer and is associated with poor treatment tolerance and increased mortality. Although GLIM criteria have standardized its diagnosis, the integration of morphofunctional parameters may improve risk stratification.

Methods: This multicenter observational study included 374 patients with lung cancer. Baseline assessment was performed between weeks 2 and 4 after diagnosis, including GLIM-based nutritional classification. Body composition was assessed using bioelectrical impedance, rectus femoris ultrasound, and functional tests (handgrip strength and Timed Up and Go). Logistic regression, ROC curves, random forest, and six-month survival analyses were performed.

Results: Malnutrition was present in 55.6% of patients (22.7% severe). Morphofunctional parameters worsened across GLIM categories, with reductions in phase angle, fat-free mass, body cell mass, and rectus femoris area, alongside poorer functional performance. Survival was significantly lower in severe malnutrition compared with well-nourished (p < 0.001) and moderate groups (p = 0.002), with no differences between well and moderate (p = 0.153). Severe malnutrition independently predicted mortality (HR 3.28, 95% CI 2.08–5.18; p < 0.001), while moderate malnutrition was not significant.

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Conclusion: GLIM-defined malnutrition is common and clinically relevant in lung cancer. Morphofunctional assessment provides added value for identifying severe malnutrition and predicting short-term mortality. Parameters such as BCMI, FFMI, and phase angle may serve as practical tools to improve early risk stratification in clinical practice.

References: Cederholm T, et al. GLIM criteria for the diagnosis of malnutrition - A consensus report from the global clinical nutrition community. Clin Nutr. 2019 Feb;38(1):1-9. doi: 10.1016/j.clnu.2018.08.002

Disclosure of Interest: None declared