P326 - THE RELATIONSHIP BETWEEN ALLEVIATION OF ADVERSE EVENTS IN CANCER THERAPY AND DIET: PROTOCOL FOR A PROSPECTIVE AND OBSERVATIONAL COHORT STUDY

P326

THE RELATIONSHIP BETWEEN ALLEVIATION OF ADVERSE EVENTS IN CANCER THERAPY AND DIET: PROTOCOL FOR A PROSPECTIVE AND OBSERVATIONAL COHORT STUDY

H.-K. Choi^1,*, S.-H. Park¹, J. Lee¹

¹Korea Food Research Institute, Iseo-myeon, Wanju-gun, Korea, Republic Of

Rationale: Cancer is the leading cause of death in South Korea, and treatment-related side effects can impair quality of life and treatment adherence. Nutritional management plays a key role in mitigating these effects, as cancer therapies often affect appetite, digestion, and nutrient absorption. Genetic variations such as single-nucleotide polymorphisms (SNPs) may influence nutrient metabolism and drug response, suggesting potential for personalized nutrition.

Methods: A cohort of 600 participants aged 20 and older will be enrolled. Data collection includes dietary intake (via cancer-specific FFQ, PMID: 36839367), treatment-related adverse events (assessed by CTCAE v5), clinical and biochemical data, lifestyle factors, and SNP profiles from saliva using the Axiom Korean Biobank Array 1.1 (827,000 SNP markers). Clinical data will be collected at baseline and annually until 2026. Lifestyle and medical histories will be surveyed. Ethical approval was obtained from the Severance Hospital IRB (4-2021-1110), and all participants will provide informed consent.

Results: The primary outcome is to identify dietary factors that alleviate chemotherapy side effects. The secondary outcome is to assess the link between nutritional status and survival. Findings may lead to new dietary guidelines tailored to Korean cancer patients.

Conclusion: This study integrates clinical, nutritional, and genomic data to examine how diet and SNPs influence treatment tolerance and side effects. The results may support personalized nutrition strategies that enhance treatment adherence and quality of life. Despite limitations such as self-reporting bias, limited SNP scope, and patient heterogeneity, the study offers a foundation for precision nutrition in cancer care and calls for future validation in diverse populations.

Disclosure of Interest: None declared