P631 - ASSOCIATIONS OF POLYPHARMACY AND MEDICINE USE WITH THE RISK OF UNDERNUTRITION IN A CROSS-SECTIONAL MULTICENTRE SAMPLE OF OUTPATIENTS WITH CHRONIC HEART FAILURE

P631

ASSOCIATIONS OF POLYPHARMACY AND MEDICINE USE WITH THE RISK OF UNDERNUTRITION IN A CROSS-SECTIONAL MULTICENTRE SAMPLE OF OUTPATIENTS WITH CHRONIC HEART FAILURE

R. Valdiviesso^1,2,*, M. Cunha Rodrigues^1,3, I. Marques^4,5, A. Teixeira⁶, R. Baptista^7,8, T. F. Amaral^1,3, N. Borges^1,2

¹Faculty of Nutrition and Food Sciences of the University of Porto, ²RISE-Health, Faculty of Nutrition and Food Sciences of the University of Porto, ³INEGI – Institute of Science and Innovation in Mechanical and Industrial Engineering, LAETA - Associate Laboratory for Energy, Transports and Aerospace, ⁴Instituto de Ciências Biomédicas Abel Salazar, ⁵Internal Medicine Service, Centro Hospitalar Universitário de Santo António, Porto, ⁶Serviço de Saúde da Região Autónoma da Madeira, EPERAM, Funchal, ⁷Faculty of Medicine of the University of Coimbra, Coimbra, ⁸Cardiology Department, Centro Hospitalar Entre Douro e Vouga, Santa Maria da Feira, Portugal

Rationale: Undernutrition is related to hospitalisation and mortality in heart failure (HF), and both conditions are related with the concomitant use of several medicines. This work intends to explore the associations between polypharmacy, medicine use, and undernutrition risk (UR) in HF patients.

Methods: A sample of HF outpatients was recruited from 3 hospitals. UR was assessed using MUST for those <65 years, and MNA-SF for older patients. Polypharmacy was defined as the use of ≥5 medicines. Associations between UR and 15 medicines (β-blockers, angiotensin receptor blockers/angiotensin converting enzyme inhibitors (ARB/ACEI), Sacubitril/Valsartan, MRA, loop and other diuretics, antiarrhythmics, nitrates, statins, SGLT2 inhibitors, anxiolytics, antidepressants, ASA, and anticoagulants), were analysed using a logistic model, adjusted for sex, age, NYHA classes, HF phenotype, diabetes, infarction, and atrial fibrillation. Results are depicted in odds ratios and 95% confidence intervals (OR;95%CI).

Results: A total of 207 HF outpatients (44.4% women, 71±12.5y) were analysed, of which 35.7% were at UR. Participants used a median of 7 daily medicines, but polypharmacy (89.3% of the sample) was not associated with undernutrition. Men had lower odds of undernutrition (0.35;0.12-0.98) and participants in NYHA class III had more than 5 times the odds of being at UR than those in class I (5.14;1.35-19.5). β-blockers (0.28;0.08-0.94) and ARB/ACEI (0.18;0.05-0.61) were associated with lower odds of UR, while antiarrhythmics had the opposite effect (4.63;1.15-18.65).

Conclusion: Polypharmacy was very frequent in this sample but was not associated with UR. As arrhythmias are common in the undernourished, the prescription of antiarrhythmics is somewhat expected, but the potential protective associations of β-blockers and ARB/ACEI deserve further study.

Disclosure of Interest: None declared