P343 - RELATIONSHIP BETWEEN PARENTERAL NUTRITION AND CENTRAL VENOUS CATHETER-ASSOCIATED PRIMARY BLOODSTREAM INFECTION IN A CANCER CENTER

P343

RELATIONSHIP BETWEEN PARENTERAL NUTRITION AND CENTRAL VENOUS CATHETER-ASSOCIATED PRIMARY BLOODSTREAM INFECTION IN A CANCER CENTER

L. Matos^1,*, J. P. Vidotto¹, W. F. de jesus¹, I. L. A. F. Silva¹, R. R. da Silva¹, R. Barborsa¹, C. D. Silva ¹, C. C. Silva¹

¹Oncology, Ac Camargo Cancer Center, Sao paulo, Brazil

Rationale: Central venous catheter-associated primary bloodstream infection (CVC-PSI) is a significant complication in oncology patients, increasing morbidity, mortality, and hospital costs. Malnutrition, common in this population, is a risk factor for these infections. Understanding the relationship between parenteral nutrition (PN) and the incidence of CVC-PSI, along with infection prevention practices related to healthcare-associated infections (HAIs), is essential for effective clinical decision-making.

Methods: This retrospective observational study analyzed CVC-PSI in patients receiving PN at a Brazilian Cancer Center from July 2023 to February 2025.

Results: ver 20 months, 12,956 patients/day received PN, of which 20 developed CVC-PSI, representing 1.5% of the total population. A total of 22 cases of CVC-PSI associated with PN were recorded, resulting in an Incidence Density (ID) of 1.69. The monthly average of CVC-PSI associated with PN was 0.17%, with an average duration of PN of 18 days. The average age of patients with CVC-PSI was 58 years, with a predominance of females, all having solid tumors. The main identified microorganisms were gram-positive cocci, particularly Staphylococcus epidermidis, in 55% of cases. It was noted that 77% of cases occurred in patients with peripherally inserted central catheters (PICC), the most commonly used for infusion in this service.

Conclusion:  The results indicate that the infusion of PN in oncology patients does not increase the risk of CVC-PSI, especially when venous access care bundles are adopted. Good practice protocols for catheter handling and prevention of HAIs are essential to prevent PN-associated CVC-PSI, allowing for the safe use of this nutritional therapy. 

Disclosure of Interest: None declared