PP196 - FROM BODY COMPOSITION PROFILING TO NUTRITIONAL RISK: CLINICAL RELEVANCE IN GASTROINTESTINAL CANCERS
PP196
FROM BODY COMPOSITION PROFILING TO NUTRITIONAL RISK: CLINICAL RELEVANCE IN GASTROINTESTINAL CANCERS
G. Porciello1,*, A. Luongo1, N. Russo1, E. Racca2, M. D'Amico3, E. Palumbo1, S. Vitale1, F. P. M. Di Carlo1, P. Rocco1, S. Coluccia1, E. Coppola4, V. Turrà5, A. Crispo1, S. Pignata4 on behalf of NUTRISCREEN Collaborative Group
1Epidemiology and Biostatistics Unit, 2Experimental Clinical Abdominal Oncology Unit, 3Colorectal Surgical Oncology Abdominal Oncology Department, 4Department of Urology and Gynecology, 5Dietetics and Artificial Nutrition, , Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale", Naples, Italy
Rationale: Gastrointestinal cancers and their treatments can compromise nutritional status and increase the risk of malnutrition and sarcopenia. This study evaluates the clinical relevance of bioelectrical impedance analysis (BIA) for early identification of nutritional impairment and risk in newly diagnosed GI cancer patients.
Methods: Gastric, pancreatic, rectal, and liver cancers patients data were used. Risks of malnutrition and sarcopenia were assessed using NRS-2002 and the SARC-F questionnaire, respectively. Nutritional assessment included body composition parameters derived from BIA. Principal component analysis (PCA) and cluster analysis were performed to identify distinct body composition profiles combining BIA-derived parameters. Multivariable adjusted logistic regression models assessed associations between body composition profiles and nutritional risk.
Results: 189 patients (mean age 66.0 ± 11.0) were analysed. Overall, 36.5% were at risk of malnutrition and 32.3% at risk of sarcopenia. PCA and k-means identified two body composition profiles: High-Quality Muscle (HMP; n=99) and Low-Quality Muscle (LMP; n=90). LMP had more females (63.3% vs 9.1%, p<0.001), higher malnutrition (47.8% vs 27.3%, p=0.005) and sarcopenia risk (44.4% vs 21.2%, p=0.002), lower PhA (5.2 ± 0.9 vs 6.3 ± 1.2), lower BCMI (8.8 ± 1.2 vs 11.7 ± 1.5) and higher ECW:ICW (1.0 ± 0.2 vs 0.8 ± 0.2). LMP was independently associated with malnutrition (OR=3.52, p=0.008) and sarcopenia (OR=3.32, p=0.011).
Conclusion: The Low-Quality Muscle Profile (LMP) was linked to poorer nutritional and body composition parameters than the High-Quality Muscle Profile (HMP). Body composition profiling offers a non-invasive tool to guide early, targeted nutritional interventions and support muscle health in gastrointestinal cancer patients.
Disclosure of Interest: None declared