P911 - FEASIBILITY AND PRELIMINARY EFFECTS OF THE PLANETARY HEALTH DIET ON OBESITY-RELATED OUTCOMES: A PILOT RANDOMIZED CONTROLLED TRIAL

P911

FEASIBILITY AND PRELIMINARY EFFECTS OF THE PLANETARY HEALTH DIET ON OBESITY-RELATED OUTCOMES: A PILOT RANDOMIZED CONTROLLED TRIAL

T. Lu^1,2,*, D. Zhu¹, X. Zhong¹, Y. Zhang¹, J. Wang¹, Y. Wang¹, J. Du³, J. Kan³, E. Y.-Z. Huang³, Y. Zhang⁴, L. Xu^1,5,6

¹School of Public Health, Sun Yat-sen University, Guangzhou, China, ²Department of Nutritional Sciences, King's College London, London, United Kingdom, ³Nutrilite Health Institute, Nutrilite Health Institute, Shanghai, ⁴Health Management Center, 1st Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, ⁵School of Public Health, the University of Hong Kong, Hong Kong, Hong Kong SAR, ⁶Institute of Applied Health Research, University of Birmingham, Birmingham, United Kingdom

Rationale: Observational studies reported the associations between planetary health diet (PHD) and various health outcomes, but randomized controlled trials (RCTs) are lacking. This first pilot RCT primarily assessed the feasibility of implementing the PHD and explored effects on health-related indicators.

Methods: A total of 24 individuals aged 18+ years were enrolled and randomly allocated (1:1) to either the intervention group (PHD for eight weeks) or a control group (conventional diet). Data were collected at baseline and post-intervention, with anthropometric parameters assessed biweekly. The primary aim was on the feasibility of trial procedures. Secondary outcomes included changes in anthropometric, biochemical and gut microbiome indicators. The trial was registered at ClinicalTrials.gov.

Results: The intention-to-treat (ITT) analysis included 24 participants (12 in each group) while the per-protocol (PP) analysis included 23 participants (1 in control group dropout). Feasibility outcomes demonstrated successful implementation, with 60% recruitment, 95% retention, and low difficulty, high understanding and willingness to adhere to PHD. Preliminary exploratory analysis indicated greater reductions in body fat mass (adjusted β (95% confidence interval (CI)): -1.25 (-2.41, -0.10) kg), waist circumference (-2.58 (-4.67, -0.49) cm), waist-to-height ratio (-0.02 (-0.03, -0.01)), and body roundness index (-0.26 (-0.46, -0.05)). PP analysis showed similar results. No significant differences were observed for biochemical or gut microbiome indicators.

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Conclusion: The PHD intervention was feasible in terms of recruitment, retention and adherence. Preliminary findings suggest potential benefits for obesity-related outcomes. Larger, fully powered RCTs are needed to assess the definitive effects of PHD on biochemical markers and gut microbiome indicators.

Disclosure of Interest: None declared