P097 - BLADDER CANCER: IDENTIFYING THE FACES OF RECURRENCE IN RABAT.

P097

BLADDER CANCER: IDENTIFYING THE FACES OF RECURRENCE IN RABAT.

N. Denise Edith Tatiana^1,2, L. Imane^1,2, A. Falone^2,3, W. Carine^1,2, R. yassine ^1,2, N. Hubert^1,2, K. Tayeb^1,2,*, H. Khalid^1,2

¹Radiotherapy, national institute of oncology, ²Faculty of Medicine and Pharmacy, Mohammed V University, ³oncology, national institute of oncology, rabat, Morocco

Rationale: Non-muscle-invasive bladder tumors (NMIBC) exhibit a high risk of recurrence after initial treatment, significantly impacting morbidity and healthcare costs. Identifying prognostic factors for recurrence is essential for personalized management. This single-center retrospective study evaluates factors associated with the risk of recurrence in a cohort of NMIBC patients followed at the National Institute of Oncology in Rabat.

Methods: Our study included 25 patients diagnosed with NMIBC and followed between January 2020 and March 2025. Clinical (age, sex, smoking), histopathological (initial stage, grade, CIS, multifocality, size), and follow-up (duration, recurrence) data were extracted from medical records. Descriptive and univariate statistical analyses (Chi-square/Fisher, Mann-Whitney) were performed to evaluate the association of factors with recurrence (p<0.05 threshold).

Results: The cohort comprised 76% males, with a median age at diagnosis of 67 years. Smoking was frequent (68%). Initial stages were Ta (40%), T1 (36%), and CIS (24%). High grade (G3) was present in 52%, and 44% had multifocal tumors (median size 2 cm). After a median follow-up of 30 months, 48% (n=12) experienced recurrence. Univariate analysis showed a significant association between high grade (p=0.03), the presence of concomitant CIS (p=0.01), and tumor multifocality (p=0.04) with recurrence. No significant association was observed for age, sex, smoking, or initial stage (Ta vs T1).

Conclusion: This preliminary study on a limited cohort of Moroccan patients with NMIBC suggests that high grade, concomitant CIS, and tumor multifocality are prognostic factors for recurrence. These results highlight the importance of these histopathological characteristics for risk stratification and personalized follow-up. Prospective studies with larger sample sizes are needed to confirm these findings and identify other potential factors.

Disclosure of Interest: None declared