P010 - ASSOCIATION BETWEEN NUTRITIONAL STATUS AND TREATMENT RESPONSE AND SURVIVAL IN PATIENTS TREATED WITH CHEMORADIOTHERAPY FOR CERVICAL CANCER: A PROSPECTIVE STUDY OF 120 PATIENTS

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P010

ASSOCIATION BETWEEN NUTRITIONAL STATUS AND TREATMENT RESPONSE AND SURVIVAL IN PATIENTS TREATED WITH CHEMORADIOTHERAPY FOR CERVICAL CANCER: A PROSPECTIVE STUDY OF 120 PATIENTS

C. Ezzouitina1,2, A. Majdi1,2, F. Z. CHRAA1,2, M. Farina1,2, A. Lachgar1,2, K. Nouni1,2, H. El Kacemi1,2, T. Kebdani1,2,*, K. Hassouni1,2

1Department of Radiotherapy, National Institute Of Oncology, 2Medicine, Mohammed V University, Rabat, Morocco

 

Rationale: This study aims to evaluate the association between malnutrition,treatment tolerance,and survival outcomes in patients with cervical cancer undergoing chemoradiotherapy.

Methods: This is a prospective study conducted in the Radiotherapy Department of the National Institute of Oncology in Rabat between June and December 2024.The study includes patients diagnosed with locally advanced cervical cancer,treated with concurrent chemoradiotherapy based on cisplatin.

The baseline nutritional status (0D) was assessed using the Global Leadership Initiative on Malnutrition criteria,as well as Body Mass Index.

Nutritional and oncological data were collected at day 15 (15D) and day 30 (30D) after the initiation of chemoradiotherapy.

Results: A total of 120 patients with locally advanced cervical cancer were included in the study. Baseline nutritional assessment at day 0 showed that: 62.5% of patients were not malnourished, 20.83% had moderate malnutrition, 16.67% had severe malnutrition.

A significant association was observed between nutritional status at 0D and chemoradiotherapy toxicity at day 15D and day 30D, patients with moderate or severe malnutrition had a higher incidence of severe metabolic alterations leading to treatment interruptions.

The rate of dose reduction or temporary treatment discontinuation was significantly higher in malnourished patients.

At D30, tumor response evaluation showed that well-nourished patients had a significantly higher overall response rate to chemoradiotherapy compared to malnourished patients.

 

Conclusion: Our results highlight the essential role of nutritional assessment and intervention in enhancing treatment efficacy and survival in cervical cancer patients.

Disclosure of Interest: None declared