PD419 - AIRWAY INFLAMMATION AND DIETARY ANTIOXIDANT INADEQUACY IN ASTHMA-COPD OVERLAP SYNDROME: EXPLORING THE LINK BETWEEN TYPE-2 INFLAMMATORY BIOMARKERS AND NUTRITIONAL INTAKE PATTERNS
PD419
AIRWAY INFLAMMATION AND DIETARY ANTIOXIDANT INADEQUACY IN ASTHMA-COPD OVERLAP SYNDROME:
EXPLORING THE LINK BETWEEN TYPE-2 INFLAMMATORY BIOMARKERS AND NUTRITIONAL INTAKE PATTERNS
S. Sahoo1,*, K. C. Jena2
1Dietetics, Restora Healthcare Chest and Diet Clinic, 2Pulmonary Medicine, Apollo Hospitals , Bhubaneswar, India
Rationale: Asthma-COPD overlap syndrome (ACOS) is characterized by heightened type-2 inflammation driven by eosinophilic and allergic pathways. Antioxidant help counter oxidative stress and modulate inflammatory signaling. This study evaluated whether patients with higher inflammatory burden demonstrate inadequate antioxidant intake and compromised nutritional status.
Methods: In this cross-sectional study, 1050 clinically stable ACOS patients (mean age 64.3 ± 8.7 years; 68% male) diagnosed using GINA/GOLD criteria were assessed. Type-2 inflammation was defined by serum total IgE (>100 IU/mL) and blood eosinophils (≥300 cells/μL). Dietary intake was obtained using structured 24-hour recall and compared with ICMR recommendations, focusing on energy, protein, and antioxidant-rich food groups. Nutritional status was evaluated using Subjective Global Assessment and BIA-derived fat-free mass index . Pulmonary function included FEV1% predicted and DLCO.
Results: Elevated IgE and eosinophilia were observed in 61% and 48% of participants, respectively. Mean FEV1 was 49.6 ± 18.2% predicted, and DLCO was reduced in 71% (62.4 ± 13.5%). Average energy intake was 1435 ± 256 kcal/day, with 64% below requirement, while mean protein intake was 0.76 ± 0.21 g/kg/day, inadequate in 58%. Intake of antioxidant-rich foods was consistently low, with diets dominated by cereal-pulse combinations and limited fruits, vegetables, and nuts. Patients with elevated inflammatory markers showed poorer dietary diversity & indicating a combined inflammatory-nutritional impairment.
Conclusion: Incorporating dietary antioxidant assessment into routine ACOS care may help identify modifiable risk factors. Longitudinal studies with detailed micronutrient evaluation are required to confirm causality and guide targeted nutrition-based interventions.
Disclosure of Interest: None declared