Sep 6, 2026
4:00 PM5:30 PM
ePoster presentations
ePoster Stage 4: Techniques to assess nutritional status
Stavroula CHALOULAKOU
PP277 - ESTIMATING THE ANABOLIC ROLE OF GLUCOSE METABOLISM IN ABDOMINAL CATASTROPHE PATIENTS USING INDIRECT CALORIMETRY
PP277
ESTIMATING THE ANABOLIC ROLE OF GLUCOSE METABOLISM IN ABDOMINAL CATASTROPHE PATIENTS USING INDIRECT CALORIMETRY
O. Sobotka1,2,*, A. Chehal1, J. Visek1, P. Skorepa1,2, L. Sobotka1
13rd Department of Internal Medicine – Metabolic Care and Gerontology, University Hospital in Hradec Kralove, 2Department of Military Internal Medicine and Military Hygiene, University of Defence, Military Faculty of Medicine, Hradec Kralove, Czech Republic
Rationale: Carbohydrates (CHO) are not barely energy source but essential building blocks for tissue repair and inflammation. Thus, glucose is vital for restoring cell mass and wound healing in abdominal catastrophe patients. Cellular anabolism is characterized by a respiratory quotient (RQ) exceeding the food quotient, which depends on dietary CHO. Assessing RQ alongside resting energy expenditure (REE) helps estimate the anabolic fraction of glucose metabolism. We evaluated this anabolic role during nutritional support in abdominal catastrophe patients.
Methods: Forty-five patients receiving parenteral or enteral nutrition for abdominal catastrophes were included in retrospective analysis. Resting energy expenditure (REE) along with RQ, were measured regularly using a Q-NRG metabolic monitor (COSMED). We analyzed RQ changes and oxidized fat/CHO proportions relative to nutritional composition. Data are presented as medians and interquartile range.
Results: Energy balance across the cohort was positive (221.4 kcal/d [79.9–811.7]). RQ correlated positively with absolute CHO intake (r=0.56) and the CHO/REE ratio, but was not influenced by lipid or protein intake. A significant CHO portion was non-oxidative (120.6 g/d [27.0–479.3]); despite inter-patient variations, most contributed to a positive CHO balance. Additionally, non-oxidative CHO metabolism correlated positively with protein intake. These patterns suggest non-oxidative glucose is actively utilized for cellular anabolism rather than mere oxidation.
Conclusion: CHO (especially glucose) are critical building blocks for cellular anabolism. Monitoring energy expenditure and RQ via indirect calorimetry effectively estimates the anabolic fraction of glucose metabolism, guiding personalized CHO recommendations in critically ill patients.
Disclosure of Interest: None declared