Sep 15, 2025
1:00 PM2:00 PM
Poster Session
P924 - NUTRITIONAL TEAM AND DESIGNATED SOFTWARE REDUCED THE IMPROPER MEDICATION HANDLING BY 80%
P924
NUTRITIONAL TEAM AND DESIGNATED SOFTWARE REDUCED THE IMPROPER MEDICATION HANDLING BY 80%
B. Pantolini1,2,*, T. Garraffa1,2, M. S. Fusco1,2, G. Pavanello1,2, E. Dalla Fontana1,2, A. Pirrone1,2, M. Risicato3,4, A. Cavioni3,4, E. M. Tirelli3,4, A. Mascheroni3,4, R. Cursano1,2
1UOC Farmacia Ospedaliera, ASST Melegnano Martesana, 2Clinical Pharmacy, 3UOSD Dietologia e Nutrizione Clinica, ASST Melegnano Martesana, 4 Clinical Nutrition, Milano, Italy
Rationale: Administering drugs via PEG is often inappropriate due to the manipulation of unsuitable formulations.Errors such as crushing modified-release tablets or neglecting drug–nutrient interactions may reduce efficacy,cause toxicity,obstruct feeding tubes.These risks are amplified in elderly,polymorbid patients.
Methods: In the context of the multicentric study “CRONICITA’ SICURA”,funded by AIFA,our hospital implemented a multidisciplinary initiative to optimize medication use in polymorbid patients over 65. A subgroup of 23 patients receiving chronic EN was enrolled for focused analysis.Clinical pharmacist worked alongside physicians using a software to analyzed interactions and pharmacokinetic,pharmacodynamic and pharmaceutical technique aspects of the active ingredients.
Results: Of 159 medications,53% were inappropriately handled.Common issues included crushing of modified-release or enteric-coated tablets, inappropriate dilution, etc.Pharmacists recommended 69 therapeutic alternatives more suitable for enteral use,including liquid formulations and soluble tablets. When commercial alternatives were unavailable, personalized galenic preparations were prescribed.85 drug interactions(48 major,30 moderate,6 minor) and 1 food-drug interaction were identified.2 ADR were detected and formally reported to the AIFA pharmacovigilance system.In response,modifications to administration timing or therapeutic deprescribing(guided by the Beers and STOPP criteria)were implemented to minimize iatrogenic risks.As a result of the intervention,the incidence of inappropriate drug handling was reduced by 81%.
Conclusion: Our findings emphasize the value of a structured,pharmacist-led review in patients receiving enteral nutrition.Multidisciplinary collaboration significantly improved drug safety and appropriateness.Standardized protocols and ongoing education are essential to reduce preventable errors in this vulnerable population.
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Disclosure of Interest: None declared