P965 - DIABETIC TRENDS AND ASSOCIATED MORTALITY AMONG TUBERCULOSIS PATIENTS: A LARGE-SCALE STUDY FROM INDONESIA’S NATIONAL HEALTH INSURANCE DATA

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P965

DIABETIC TRENDS AND ASSOCIATED MORTALITY AMONG TUBERCULOSIS PATIENTS: A LARGE-SCALE STUDY FROM INDONESIA’S NATIONAL HEALTH INSURANCE DATA

N. N. Afifa1,*, P. L. Putra2, D. Sunardi1,3, W. Lestari1

1Department of Nutrition, Universitas Indonesia, Jakarta, Indonesia, 2Department of Computer and Information Science, University of Pennsylvania, Philadelphia, United States, 3 Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia

 

Rationale: The dual burden of tuberculosis (TB) and type-2 diabetes mellitus (DM) comorbidity (TB-DM) poses a significant public health concern, as DM increases susceptibility to TB infection and worsen treatment outcomes. This study aims to explore the risk factors and trends associated with TB-DM mortality.

Methods: A cross-sectional analysis was conducted using sample data from Indonesia’s National Health Insurance database, encompassing 90,524 hospitalized TB patients recorded between 2019 and 2023. Logistic regression was employed to identify risk factors for TB-DM mortality. Trends in TB-DM prevalence and mortality rates were evaluated using non-parametric tests.

Results: From 2019 to 2023, the prevalence of TB patients with DM remained consistently high at approximately 11.67%. TB-DM patients had a significantly higher mortality rate (10.7%) compared to non-DM TB patients (4.8%, p <0.001). Male sex [OR (95% CI): 1.18 (1.04–1.34)], age >65 years [1.33 (1.17–1.52)], malnutrition [2.94 (2.14–4.04)], anaemia [2.97 (2.59–3.41)], chronic kidney disease [3.33 (2.83–3.92)], and residence of Java Island [1.27 (1.12–1.44)] were associated with increased mortality among TB-DM patients.

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Conclusion: This nationally representative study indicates that DM comorbidity substantially increases mortality risk in TB patients, emphasizing the need for comprehensive care strategies. The identification of key risk factors, including malnutrition and anaemia, highlights the critical role of integrating tuberculosis treatment with targeted medical nutrition therapy and metabolic interventions. Collaborative management approaches are essential to reduce mortality and improve the prognosis of TB-DM patients.

Disclosure of Interest: None declared