P059 - EFFECT OF BMI CHANGES ON CLINICAL PROGNOSIS IN CRITICALLY ILL PATIENTS

P059

EFFECT OF BMI CHANGES ON CLINICAL PROGNOSIS IN CRITICALLY ILL PATIENTS

F. Xi^1,*, N. Zheng¹, D. Wang², R. Teng², S. Tan³

¹Department of Intensive Care Unit, Women's Hospital of Nanjing Medical University (Nanjing Women and Children's Healthcare Hospital), ²Department of Intensive Care Unit, Women's Hospital of Nanjing Medical University (Nanjing Women and Children's Healthcare Hospital), Nanjing, ³Department of General Surgery, Shanghai Clinical Nutrition Research Center, Zhongshan Hospital, Fudan University, Shanghai, China

Rationale:  Critically ill patients have a higher proportion of changes in BMI in the early stages after ICU admission. However, whether BMI changes affect the clinical prognosis of patients has not been fully proven. To prospectively observe the changes in BMI of critically ill patients before and after ICU admission, and to evaluate whether high ΔBMI is associated with poor prognosis.

Methods: The study was designed in a prospective cohort study with 6-month follow-up. Inclusion criteria :(1) Age ＞ 18 years old, (2) patients admitted to ICU and APACHE II score > 6，(3) The weight change of patients was recorded completely; Exclusion Criteria: (1) pregnancy, (2) psychiatric disorders, (3) loss to follow-up. Univariate and multivariate logistic regression were used to evaluate the impact of different baseline BMI categories (<25 kg/m2, ≥25 kg/m2) on clinical prognosis. Univariate and multivariate logistic regression analyses were used to assess the association between changes in BMI and outcomes.

Results: 35 ICU patients were finally included in this study. After adjusting for confounding variables, we found that the BMI ≥25 kg/m2 group was significantly associated with the occurrence of complications compared with the BMI<25 kg/m2 group (OR=58.08, 95%CI: 3.00-1125.95, P=0.007). However, after adjusting for confounding variables, multivariate logistic regression analysis showed that ΔBMI (OR=1.16, 95%CI: 0.51-2.67, P=0.726) was not significantly associated with total complications.

Conclusion: This study shows that BMI changes have no significant correlation with the clinical prognosis of severe patients, and it is not enough to reflect the nutritional status and prognosis of patients through BMI changes, and more indicators are needed for further research.

Disclosure of Interest: None declared