PT05. - EVALUATION OF THE RELATIONSHIP BETWEEN BODY ROUNDNESS INDEX AND THE RISK OF CARDIORENAL SYNDROME IN PATIENTS WITH CHRONIC KIDNEY DISEASE

PT05.

EVALUATION OF THE RELATIONSHIP BETWEEN BODY ROUNDNESS INDEX AND THE RISK OF CARDIORENAL SYNDROME IN PATIENTS WITH CHRONIC KIDNEY DISEASE

S. SAHIN BAYRAM¹, B. ARI GEDİK^1,2,*, E. KÖKSAL²

¹Nutrition and Dietetics, Selcuk University, Konya, ²Nutrition and Dietetics, Gazi University, Ankara, Türkiye

Rationale: This study examines the association between Body Roundness Index (BRI)—proposed to better reflect body composition than Body Mass Index (BMI)—and cardiorenal syndrome (CRS) risk in hemodialysis patients, aiming to guide early diagnosis and risk management strategies.

Methods: This single-center, cross-sectional pilot study included 54 patients with chronic kidney disease receiving hemodialysis for at least six months. Data were collected in March 2025. Malnutrition-Inflammation Score (MIS) was used to assess nutritional and inflammatory status. Anthropometric data, lab parameters, and demographic variables were recorded. BRI, BMI, and eGFR were calculated using the CKD-EPI formula. Spearman correlation and multiple linear regression analyses were performed to explore associations.

Results: BRI showed a significant, moderate positive correlation with CRP (r=0.377, p=0.006), but was not significantly related to eGFR, K, Na, P, ACR, or MIS (p>0.05). BMI was weakly but significantly correlated with CRP (r=0.297, p=0.034), and had a borderline inverse relationship with MIS (r=-0.262, p=0.064). Regression analysis revealed that higher BRI was significantly associated with elevated CRP (p = 0.047) and ACR (p = 0.026), while BMI was linked only to MIS (p = 0.025). Additionally, the strength and significance of the association between BRI and CRP remained consistent across both correlation and regression analyses, further reinforcing the link between body roundness and systemic inflammation. Multicollinearity was noted, especially for ACR (VIF=13.250) and eGFR (VIF=12.317).

Conclusion: These results suggest that BRI may have a stronger and broader association with CRS-related inflammatory and renal parameters than BMI. Larger studies are warranted to confirm its clinical relevance.

Disclosure of Interest: None declared