P312 - 10-YEAR PROGNOSTIC VALUE OF BODY COMPOSITION IN BREAST CANCER: IMPLICATIONS FOR TREATMENT AND SURVIVAL

P312

10-YEAR PROGNOSTIC VALUE OF BODY COMPOSITION IN BREAST CANCER: IMPLICATIONS FOR TREATMENT AND SURVIVAL

D. Hopanci Bicakli^1,*, A. Gecgel¹, O. Ozkan¹, A. Aktuna², M. M. Isci¹, S. Erol¹, D. Aydoğan¹

¹Medical Oncology Department, Ege University Medical Faculty Hospital, Izmir, ²Public Health , Bandırma Onyedi Eylül University, Balıkesir, Türkiye

Rationale: Breast cancer is the most common malignancy in women, with body composition influencing treatment response, disease progression, and survival. This study explores the effect of nutritional status and body composition on recurrence and outcomes over 10 years.

Methods: Nutritional status was assessed using the Subjective Global Assessment (SGA), anthropometric measurements (BMI, calf circumference (CC), upper mid-arm circumference (MUAC)), triceps skin fold (TSF), and body composition analysis (BIA). After 10 years, patients' outcomes (healthy, recurrence, or deceased) were reassessed. Descriptive statistics and analysis were performed using SPSS version 24.

Results: The study included 527 female patients (60age, min-max: 22–96). 83.5% of the patients had undergone surgery. According to the SGA classification, 55.2% were classified as SGA-A, 30.0% as SGA-B, and 14.8% as SGA-C. After a 10-year follow-up, the recurrence rate was 30.0%, and the mortality rate was 29.0%.In patients with SGA-C, the recurrence rate (47.4%) was higher compared to SGA-A (25.1%) and SGA-B (30.4%) levels (p=0.001). Patients with lower fat percentage had a higher recurrence rate (p=0.018). No significant difference was found between the groups regarding body mass index (BMI) (p=0.113). However, lower values were observed in the deceased group for calf circumference (CC) (p=0.015), triceps skinfold (TSF) (p<0.001), and mid-upper arm circumference (MUAC) (p=0.009). No relationship was found between osteoporosis and anthropometric measures. Additionally, there were no significant differences in recurrence or mortality rates based on Her2 positivity (p=0.054).

Conclusion: This study demonstrates that body composition and nutritional status significantly impact treatment response, recurrence, and survival in breast cancer, emphasizing their role in long-term follow-up for evaluating clinical outcomes and treatment effectiveness.

Disclosure of Interest: None declared