P375 - VITAMIN D STATUS IS ASSOCIATED WITH TUMORAL ACTIVITY MARKER IN EARLY BREAST CANCER

P375

VITAMIN D STATUS IS ASSOCIATED WITH TUMORAL ACTIVITY MARKER IN EARLY BREAST CANCER

T. M. Montalvão-Sousa^1,*, P. D. A. Ferreira¹, N. L. Colombelli², R. M. Lima²

¹Graduate Program in Human Nutrition, ²Graduate Program in Physical Education, Universidade de Brasília, Brasília, Brazil

Rationale: This study aims to investigate the association between vitamin D status and LDH in women with early-stage breast cancer (BC) before initiating clinical treatment.

Methods: This cross-sectional study prospectively analyzed 53 BC women prior to clinical treatment. Participants were categorized in: sufficiency and insufficiency vitamin D status. Spearman´s correlation coefficient assessed the relationship between vitamin D levels and LDH.

Results: The majority of participants (54.7%) had vitamin D insufficiency. No significant differences were observed between vitamin D status groups in relation to factors that could influence vitamin D levels. A significant negative correlation was found between vitamin D status groups and LDH (r=-0.34, p=0.02). 

Conclusion: Vitamin D levels were negatively associated with LDH, a recognized prognostic marker in BC. This finding underscores the need for further research to determine whether correcting vitamin D insufficiency before treatment onset could positively influence patient prognosis.

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        - Liu D, Wang D, Wu C, Zhang L, Mei Q, Hu G, et al. Prognostic significance of serum lactate dehydrogenase in patients with breast cancer: a meta-analysis. Cancer Manag Res. abril de 2019;Volume 11:3611–9.

        - Holick MF. Vitamin D Deficiency. N Engl J Med. 2007;

        - Maalmi H, Ordóñez-Mena JM, Schöttker B, Brenner H. Serum 25-hydroxyvitamin D levels and survival in colorectal and breast cancer patients: Systematic review and meta-analysis of prospective cohort studies. Eur J Cancer. maio de 2014;50(8):1510–21.

Disclosure of Interest: None declared