P283 - PRE-TRANSPLANT MUSCLE STATUS AS A MARKER FOR PREDICTING DIARRHOEA DURATION IN NEUTROPENIA AFTER HAEMATOPOIETIC STEM CELL TRANSPLANTATION: A SECONDARY ANALYSIS

P283

PRE-TRANSPLANT MUSCLE STATUS AS A MARKER FOR PREDICTING DIARRHOEA DURATION IN NEUTROPENIA AFTER HAEMATOPOIETIC STEM CELL TRANSPLANTATION: A SECONDARY ANALYSIS

A. Song^1,*, M. Tang¹, X. Zhang¹, Y. Zhou¹, Z. Chen¹, L. Shen², R. Xu¹

¹Department of Clinical Nutrition, ²Department of Haematology, Ren Ji Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

Rationale: Pre-transplant muscle mass and quality may be associated with post-transplant clinical outcomes. The study aims to explore if muscle status before transplantation is associated with developing diarrhoea in neutropenia.

Methods: The participants were adult patients planned for haematopoietic stem cell transplantation (HSCT), between 2022 and 2024. Muscle status was measured before transplantation, by dynamometer and bioelectrical impedance analysis. The cutoff criteria for muscle status were based on the recommendations from the Asian Working Group for Sarcopenia, as follows: Group A: grip above standard (≥ male 28kg, female 18kg) AND muscle above standard (≥ male 7kg/m², female 5.7 kg/m²); Group B: grip below standard (< male 28kg, female 18kg) OR muscle below standard (<male 7kg/m², female 5.7 kg/m²). Diarrhoea was defined as the passage of more than 3 times loose stools daily as per the Bristol Stool Chart. The information on stool frequency and consistency was collected within 14 days of transplantation. 

Results: In total, 96 patients aged 52.7±12.8 years were included in the study. Of these, 25% of enrolled patients had abnormal muscle status prior to HSCT. The prevalence of diarrhoea was 84.3%, with no significant difference between groups. Muscle status was associated with diarrhoea duration ( β= 2.1 days; 95% CI= 0.4 days, 3.9 days, p=0.02) after full adjustment. The association was more pronounced in patients diagnosed with multiple myeloma, those without melphalan treatment, and patients with insufficient pre-transplant protein intake compared to other groups.

Conclusion: Pre-transplant muscle status was associated with the duration of diarrhoea in neutropenia. These results may provide evidence to support pre-transplant nutritional assessment and intervention in short-term HSCT management. 

Disclosure of Interest: None declared