P836 - RELATIONSHIPS BETWEEN CHANGES IN SERUM KETONE BODY LEVELS AND METABOLIC EFFECTS IN PATIENTS WITH SEVERE OBESITY UNDERWENT LAPAROSCOPIC SLEEVE GASTRECTOMY

P836

RELATIONSHIPS BETWEEN CHANGES IN SERUM KETONE BODY LEVELS AND METABOLIC EFFECTS IN PATIENTS WITH SEVERE OBESITY UNDERWENT LAPAROSCOPIC SLEEVE GASTRECTOMY

A. Umemura^1,*, A. Sasaki¹, H. Kumagai¹, Y. Tanahashi¹, T. Iwasaki¹, H. Nitta¹

¹Surgery, Iwate Medical University, Yahaba, Japan

Rationale: Serum ketone bodies increase due to dynamic changes in the lipid metabolisms of patients undergoing metabolic and bariatric surgery (MBS). However, there have been few studies on the role of ketone bodies after MBS; therefore,  we aimed to clarify the role of and relationship between the changes in serum ketone bodies and weight loss, as well as between those changes and the metabolic effects after MBS.

Methods: We recruited 52 patients with severe obesity who underwent laparoscopic sleeve gastrectomy as an MBS procedure. We measured acetoacetic acid (AcAc) and β-hydroxybutyric acid (β-OHB) at the baseline, 1 month, and 6 months after LSG. Subsequently, we compared the changes in the serum ketone bodies with weight-loss effects and various metabolic parameters.

Results: At 1 month after MBS, β-OHB significantly increased (p = 0.009), then significantly decreased 6 months after MBS (p = 0.002). In addition, β-OHB in patients without type 2 diabetes (T2D) and metabolic dysfunction-associated steatohepatitis (MASH) was notably higher than in patients with T2D  at 1 month after MBS (p < 0.001). In the early phase, both AcAc and β-OHB mainly had strong positive correlations with changes in T2D- and MASH-related parameters. In the middle term after MBS, changes in both AcAc and β-OHB were positively correlated with changes in lipid parameters and chronic kidney disease-related parameters.

Conclusion: We demonstrated that the postoperative surge of ketone bodies plays a crucial function in controlling metabolic effects after MBS. These findings suggest the cause- and consequence-related roles of ketone bodies in the metabolic benefits of bariatric surgery.

Disclosure of Interest: None declared