PD1047 - PRELIMINARY EVALUATION OF MUSCLE PERFORMANCE IN MALNOURISHED PATIENTS WITH COLORECTAL CANCER

PD1047

PRELIMINARY EVALUATION OF MUSCLE PERFORMANCE IN MALNOURISHED PATIENTS WITH COLORECTAL CANCER

L. PEREZ SANTIAGO^1,*, G. González-Lorente², M. Riera-Cardona¹, D. Herrero-Gómez², J. L. Martínez-De-Juan², S. A. García-Botello^1,3, G. Aguilar⁴, G. Prats-Boluda² on behalf of SARC-UCI collaborative group

¹Department of General and Digestive Surgery, Hospital Clinico Universitario. INCLIVA Biomedical Research Institute, Colorectal Surgery Unit, ²Universitat Politècnica de València, Centro de Investigación e Innovación en Bioingeniería (Ci2B), ³Department of surgery, Universidad de Valencia, ⁴Hospital Clínico Universitario de Valencia, INCLIVA Biomedical Research Institute, Department of Anesthesiology and Critical Care, Valencia, Spain

Rationale: Malnutrition significantly impairs muscular function in colorectal cancer (CRC) patients. This study aims to determine if surface electromyographic parameters (sEMG) recorded during a sustained isometric task can objectively differentiate muscle performance between malnourished and well-nourished CRC patients.

Methods: A total of 47 CRC patients (control N=20; malnourished N=27) were recruited at Hospital Clínic Universitari de Valencia in collaboration with Ci2B. Nutritional status was assessed via Mini Nutritional Assessment (MNA), grouping patients into control (MNA≥12) and malnourished (MNA<12). Before testing, maximum voluntary contraction (MVC) was recorded for signal normalization. Subjects performed two 90-second isometric elbow flexions tasks at (90°) holding a 2kg weight; the analysis was focused on the second trial. sEMG signals from biceps brachii (BB), deltoid (DL), and triceps (TR) were recorded, band-pass filtered (20-475 Hz) and analysed using 5-second windows (50% overlap). Root mean square (RMS), median frequency (Fmed), and 90% bandwidth (BW90) were computed. Group differences were assessed using the Wilcoxon rank-sum test.

Results: Malnourished patients showed a significant increase in normalized DL RMS compared to controls (Median:0.06 mV vs 0.09 mV; p=0.04). Additionally, a significant reduction in TR Fmed was observed in the malnourished group (Median: 96.22 Hz vs 72.13Hz; p=0.02). No significant differences were found in any sEMG parameters for the BB (p>0.05), nor in BW90 for DL or TR

Conclusion: Preliminary findings indicate that sEMG parameters in theDL and TR are sensitive to nutritional status in CRC patients. The observed increase in RMS and decrease in Fmed suggest that sEMG may serve as a potential objective biomarker for assessing muscle-specific impairment patterns in malnourished oncological patients.

Disclosure of Interest: None declared