O013 - A COMPREHENSIVE ANALYSIS OF THE ASSOCIATION BETWEEN SCALES OF EORTC QLQ-C30 QUESTIONNAIRE AND CACHEXIA IN PATIENTS WITH GASTRIC CANCER

O013

A COMPREHENSIVE ANALYSIS OF THE ASSOCIATION BETWEEN SCALES OF EORTC QLQ-C30 QUESTIONNAIRE AND CACHEXIA IN PATIENTS WITH GASTRIC CANCER

X. Dai^1,*, X. Zhang¹, M. Cong¹

¹Department of Comprehensive Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

Rationale: Cancer cachexia is associated with poor QoL and reduced survival in cancer patients. The EORTC QLQ-C30 is a widely used cancer-specific health-related QoL questionnaire. Our study aimed to analyze the association of each scale with cachexia and explore its influence on survival in patients with gastric cancer and cachexia.

Methods: This multi-center cohort study enrolled 3,158 patients with gastric cancer, among whom 1,711 were diagnosed with cachexia. Logistic regression analysis was conducted to identify the individual scales significantly affected by cachexia. The Cox model was employed to evaluate the prognostic performance of scales.

Results: In this study, the median age of patients was 67.00 years, with 2,178 (69.0%) men and 980 (31.0%) women. In logistic regression analyses, scales such as role function, nausea and vomiting, loss of appetite, constipation, and diarrhea were independent scales significantly associated with cachexia. According to the ROC curves, the loss of appetite was the most significant scale associated with cachexia, followed by nausea and vomiting, role function, constipation, and diarrhea. Based on multivariate Cox analyses, the scales of physical function, role function, social function, global quality of life, financial impact, and summary score were independent risk factors for survival. The C-index and AUC value for survival prediction were the highest for the social function scale.

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Conclusion: The QoL of patients with cachexia was significantly reduced. Certain scales in the EORTC QLQ-C30 were significantly associated with cachexia, especially the loss of appetite scale, and survival outcomes in patients with gastric cancer, especially social function. Emphasizing these scales can heighten our awareness of the impact of cachexia on QoL and enhance our ability to predict the survival of patients with gastric cancer and cachexia.

Disclosure of Interest: None declared