P081 - THE ROLE OF Β-HYDROXY-Β-METHYLBUTYRIC ACID IN THE PRESERVATION OF MUSCLE MASS IN PATHOLOGICAL CONDITIONS - A SYSTEMATIC REVIEW OF THE LITERATURE

P081

THE ROLE OF Β-HYDROXY-Β-METHYLBUTYRIC ACID IN THE PRESERVATION OF MUSCLE MASS IN PATHOLOGICAL CONDITIONS - A SYSTEMATIC REVIEW OF THE LITERATURE

M. V. Polytseri¹, K. Karatzi², E. Papakonstantinou², K. A. Poulia^2,*

¹ Laboratory of Dietetics and Quality of Life, Department of Food Science and Human Nutrition School of Food and Nutritional Sciences, ²Laboratory of Dietetics and Quality of Life, Department of Food Science and Human Nutrition School of Food and Nutritional Sciences, Agricultural University of Athens, Athens, Greece

Rationale: Beta-hydroxy-beta-methylbutyric acid (HMB) is a metabolite of the amino acid leucine and has been investigated regarding its role in maintaining muscle mass in different clinical conditions and ageing. Its potential applications in clinical practice include the management of sarcopenia, critical care, cancer-related muscle loss and neurological disorders.

Methods: The present systematic review investigated the efficacy of HMB supplementation in different pathological conditions and multimorbidity, regarding muscle mass preservation and the prevention of sarcopenia in humans. The systematic review was conducted according to the Prisma Guidelines and included three databases, namely PubMed, Cochrane and Google Scholar. The results were handled electronically, and thus duplicate articles were removed. All articles were examined one by one by title and abstract by two reviewers and the risk of BIAS was assessed by the Cochrane RoB2 tool.

Results: Of the 193 retrieved studies, 28 were included in the systematic review. Different study designs and dosages were implemented among the studies. Supplementation with HMB resulted in improvements in functional status and muscle mass in the older adults and in different clinical conditions, namely liver cirrhosis, cancer, hemodialysis. The duration of the studies was short term and therefore specific conclusions regarding the dosage and the efficacy of HMB in each clinical condition are difficult to reach.

Conclusion: The role of HMB seems to be important for the preservation of functionality and muscle mass integrity. Despite the increasing interest in the effects of HMB, there is a need for well conducted randomized clinical trials of long duration, in order to be able to have a more clear view of its role in older adults and in different clinical conditions that have a negative impact in muscle mass.

Disclosure of Interest: None declared